people with diabetes

	People With Diabetes Type I Diabetes Treating Diabetes Adult Diabetes Cause Of Diabetes Diabetic Diet Meal Plan Diabetes Management Software Diabetes And Exercise
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	Could you have diabetic kidney disease and not even know it? Questions to ask your doctor. ]]> Diabetes is the leading cause of chronic kidney disease Chronic kidney disease (CKD) is on the rise in part because diabetes is on the rise. If you are at risk for diabetes or have been recently diagnosed with the disease, here’s what you should know about the link between diabetes and CKD. ]]> Diabetes and minorities: What are the risks? Some ethnic groups develop diabetes at two to six times the rate of whites. If you are African American, Hispanic, Native American, Asian or Pacific Islander, here’s what you should know about your risk for diabetes. ]]> Preventing chronic kidney disease when you have diabetes Diabetes is the leading cause of chronic kidney disease. Keeping diabetes in check and early diagnosis of kidney disease could help decrease the chances of developing kidney failure. ]]> Diet tips for diabetics with kidney disease When diabetes leads to kidney disease the goal is to preserve kidney function as long as possible and manage diabetes. What you eat can affect both your blood sugar and your kidney function. A dietitian will work with you to create an eating plan that's right for you, probably using some of the diet tips presented here. ]]> Introduction Definition, causes and symptoms All about diabetes Definition, causes and symptoms What is diabetes? Diabetes is a disease that affects your body?s ability to produce or use insulin. Insulin is a hormone. When your body turns the food you eat into energy (also called sugar or glucose), insulin is released to help transport this energy to th ]]> Controlling diabetes Diabetes is the leading cause of chronic kidney disease in the United States. By controlling diabetes through lifestyle choices such as diet and exercise, taking prescribed medicines and seeing a doctor regularly, people with diabetes can usually maintain a healthy lifestyle and help prevent chronic kidney disease and kidney failure. Find out what you can do to control diabetes. ]]> Diabetes and chronic kidney disease Diabetes is the leading cause of chronic kidney disease in America. Many people with diabetes are not aware that chronic kidney disease can lead to kidney failure. However, having diabetes does not necessarily mean you will have kidney failure. Learn about the diabetes and kidney disease connection and how you can keep your kidneys healthy. ]]> Preventing diabetic kidney disease All about diabetes Preventing diabetic kidney disease How can I slow the progression of kidney disease? Keeping healthy is the most important part of delaying kidney disease. If you have diabetes and have been diagnosed with an early stage of chronic kidney disease, following your doctor?s instructions regard ]]> Get the facts Are you in control of your diabetes? If you have diabetes, your doctor advises you to keep your glucose levels in a healthy range. One of the problems that can occur for diabetics who don’t control their diabetes is the risk of kidney disease which may lead to kidney failure and dialysis. Diabetes is the leading cause of kidney disease in America. Learn how you can control your diabetes to avoid other health complications such as renal disease. ]]> Diabetic nephropathy Diabetic nephropathy means kidney damage that occurs as a result of diabetes. Researchers believe poor control of blood sugar or blood glucose levels is one of the reasons people with diabetes develop this type of kidney disease. Learn about diabetic nephropathy symptoms, diagnosis and treatment. ]]> Diabetes and peritoneal dialysis Diabetes mellitus is the number one cause of kidney failure in the United States, leading many people to need dialysis. Learn about the relationship between diabetes and chronic kidney disease (CKD), as well as how people with diabetes can choose to do the home dialysis treatment, peritoneal dialysis (PD). ]]> diabetes and pd diabetes and pd 340x160

people with diabetes guide

Why File A Zyprexa Lawsuit?
By T.Going, Fri Dec 9th

Whenever you have your health severely affected by a medication(especially in regards to lack of information or warning aboutthe potential harm), you have the right to protect yourself andto be compensated for these detrimental consequences. This isespecially true for the drug Zyprexa. Users who have takenZyprexa have developed diabetes, pancreatitis, hyperglycemia andeven death from a diabetes-induced heart attack.

Since the year 2000 the warning signs for Zyprexa have beensurfacing, but Eli Lilly didn’t begin to acknowledge theproblems until much later when the FDA intervened. In fact, theFDA finally had to order drug maker Eli Lilly to change thelabel, warning patients of the dire complications as a result ofthe drug. Hundreds of patients had adverse reactions andreported complaints of hyperglycemia, diabetes, ketoacidosis,pancreatitis and other related conditions.

Unfortunately there have been 288 cases reported inZyprexa patients, with 23 of them resulting in fatalities. WhileEli Lilly has acknowledged the dangerous life-threatening sideeffects

Diabetes Medications Related to an Increased Risk of Falls and Fall-Related Morbidity in the Elderly. - Berlie HD, Garwood CL.
OBJECTIVE: To review literature regarding the effect of diabetes medications as a contributing risk for falls and fall-related morbidity in elderly patients with type 2 diabetes. DATA SOURCES: Primary literature was identified through PubMed MEDLINE (19... (Source: SafetyLit: All (Unduplicated))<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
National Program to Eliminate Diabetes-Related Disparities in Vulnerable Populations
Funding Opportunity Number: CDC-RFA-DP10-1001 Opportunity Category: DiscretionaryFunding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCFDA Number: 93.283Eligible Applicants Others (see text field entitled "Additional Information on Eligibility" for clarification)Agency Name HHS-CDC (Source: Grants.gov)
Celiac disease in Brazilian patients: associations, complications and causes of death. Forty years of clinical experience
Conclusions - This experience is similar to those described in the world literature. Celiac disease presents the same characteristics independently of the geographic region. We recommend periodic evaluations, from childhood, independent of the duration of the diet. The key is to establish an interval between evaluations.CONTEXTO: A doença celíaca é uma enfermidade multissistêmica e autoimune que pode se manifestar em qualquer idade, em indivíduos geneticamente predispostos. OBJETIVO: Identificação das associações, complicações e causas de morte em pacientes brasileiros após longo período de acompanhamento. MÉTODOS: Foram estudados retrospectivamente 157 pacientes, 23 adolescentes e 134 adultos, 79,6% do sexo feminino e 20,4% do masculino, 75,8% ao diagnóstico e 24,2% em diet...
Young Type 2 diabetics have impaired mitochondrial response to exercise
Obese individuals who develop Type 2 diabetes early in life are unable to increase their maximal oxygen consumption in response to chronic exercise, which is likely to be due to mitochondrial abnormalities, say investigators. (Source: MedWire News - Diabetes)
Induced effects by Ruta graveolens L., Rutaceae, Cnidoscolus chayamansa McVaugh, Euphorbiaceae, and Citrus aurantium L., Rutaceae, on glucose, cholesterol and triacylglycerides levels in a diabetic rat model
In conclusion the administration of Cnidoscolus chayamansa it exerts hypoglycemic effects in a manner dose-dependent in comparison with both Ruta graveolens and Citrus aurantium. In addition, the plants evaluated induce changes in lipids levels dose-dependent. (Source: Revista Brasileira de Farmacognosia)
The characteristics of elderly burns in Shanghai
This study aims to analyse the epidemiologic characteristics of severe burn in the elderly in Shanghai and to discusses a possible prevention programme for this population.Methods: A retrospective review of all medical records of elderly patients (aged 60 and older) admitted with acute burns to the Burn Center of the RuiJin Hospital between January 1996 and December 2004 was carried out. Patient demographics, etiology of burn, mechanism of injury, burn extent, anatomical areas burned, number of operations, and outcomes were reviewed.Results: A total of 201 (5.8% of hospitalised patients) elderly patients (mean age (±SD) of 69.3±7.1 years (range 60?90 years)) were admitted. Majority of the patients were men (62.2%) and the most common etiologies were flames (52.7%) and scalds (39.8%). T...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Diabetes Experts Call For Early, Integrated Treatment Approach To Help Prevent Complications And Improve Patient Outcomes
Results from a new online survey of more than 300 practicing endocrinologists and family medicine physicians1 show that a large majority of physicians (83 percent)1 indicated that using a team of specialists early in the course of type 2 diabetes (T2D) treatment can help prevent serious T2D-related complications. However, more than nine out of 10 physicians (93 percent)1 surveyed do not believe their peers are using this team approach. The online survey was supported by Boehringer Ingelheim Pharmaceuticals, Inc. and conducted by Sermo... (Source: Health News from Medical News Today)
Diabetes Experts Call For Early, Integrated Treatment Approach To Help Prevent Complications And Improve Patient Outcomes
Results from a new online survey of more than 300 practicing endocrinologists and family medicine physicians1 show that a large majority of physicians (83 percent)1 indicated that using a team of specialists early in the course of type 2 diabetes (T2D) treatment can help prevent serious T2D-related complications... (Source: Diabetes News From Medical News Today)
Exploring Diabetes' Link To Eating Disorders
Diabetics, under the gun to better manage their disease by controlling their food intake and weight, may find themselves in the sticky wicket of needing treatment that makes them hungry, researchers said. Attempts to maintain healthy blood sugar levels and prevent weight gain may suggest an eating disorder when the disease and its treatment are to blame, said Dr. Deborah Young-Hyman, pediatric psychologist at the Medical College of Georgia's Georgia Prevention Institute... (Source: Health News from Medical News Today)
TaiGen Announces Nemonoxacin (TG-873870) Once-A-Day Oral Dosing In Diabetic Foot Infection Met Primary Endpoints
TaiGen Biotechnology Co., Ltd. announced the Phase II trial of nemonoxacin (TG-873870) in Diabetic Foot Infection (DFI) with once-a-day dosing met the primary endpoints and showed promising clinical efficacy and good tolerability. Nemonoxacin is a novel non-fluorinated quinolone that has a broad spectrum of activity against gram-positive and gram-negative bacteria and atypical pathogens. Importantly, nemonoxacin possesses activities against Methicillin-Resistant Staphylococcus aureus (MRSA) and vancomycin-resistant pathogens... (Source: Health News from Medical News Today)
Exploring Diabetes' Link To Eating Disorders
Diabetics, under the gun to better manage their disease by controlling their food intake and weight, may find themselves in the sticky wicket of needing treatment that makes them hungry, researchers said. Attempts to maintain healthy blood sugar levels and prevent weight gain may suggest an eating disorder when the disease and its treatment are to blame, said Dr... (Source: Diabetes News From Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
TaiGen Announces Nemonoxacin (TG-873870) Once-A-Day Oral Dosing In Diabetic Foot Infection Met Primary Endpoints
TaiGen Biotechnology Co., Ltd. announced the Phase II trial of nemonoxacin (TG-873870) in Diabetic Foot Infection (DFI) with once-a-day dosing met the primary endpoints and showed promising clinical efficacy and good tolerability. Nemonoxacin is a novel non-fluorinated quinolone that has a broad spectrum of activity against gram-positive and gram-negative bacteria and atypical pathogens... (Source: Diabetes News From Medical News Today)
Changing patterns in health behaviors and risk factors related to cardiovascular disease among american indians and alaska natives.
CONCLUSIONS: Diabetes, obesity, and hypertension and their associated risk factors should be studied further among urban, rural, and reservation American Indian and Alaska Native populations, and effective primary and secondary prevention efforts are critical. PMID: 20220114 [PubMed - in process] (Source: American Journal of Public Health)
The Body's Anticipation Of A Meal Can Be A Diabetes Risk Factor
Alterations in our response to the taste or smell of food may be another culprit responsible for Type 2 diabetes, according to scientists at Duke University Medical Center who have identified the specific mechanism in human specimens and in mice. When we anticipate or smell a meal, the parasympathetic nervous system triggers salivation and increases insulin production in response to the expectation that glucose will be entering the blood stream. "We think this parasympathetic response is potentially important in type 2 diabetes," said Vann Bennett, the James B... (Source: Health News from Medical News Today)
Cutting Obesity In Black, Latino New Yorkers
A $6 million grant from the National Heart, Lung and Blood Institute (NHLBI) has funded the creation of ORBIT: Obesity Related Behavioral Intervention Trials to focus on reducing obesity and obesity-related deaths in New York City's African-American and Latino communities. "African-Americans and Latinos have been disproportionately affected by the obesity epidemic, and its related risks for diabetes and heart disease," says Dr. Mary Charlson, the center's director, the William T... (Source: Health News from Medical News Today)
The Body's Anticipation Of A Meal Can Be A Diabetes Risk Factor
Alterations in our response to the taste or smell of food may be another culprit responsible for Type 2 diabetes, according to scientists at Duke University Medical Center who have identified the specific mechanism in human specimens and in mice... (Source: Diabetes News From Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
A Review of Methods Used in Long-Term Cost-Effectiveness Models of Diabetes Mellitus Treatment
(Source: PharmacoEconomics)
Prediction of wound healing in human diabetic foot ulcers by diffuse near-infrared spectroscopy: A pilot study
In conclusion, evaluation of wounds using NIR may provide an effective measurement of wound healing. NIR spectroscopy can determine wound healing earlier than that visibly assessed by current clinical approaches. (Source: Wound Repair and Regeneration)
Short Term High-Intensity Interval Training (HIT) As Effective As Moderate Long Term Endurance Exercise, Study
The excuse that there is not enough time to exercise effectively is beginning to wear thin according to evidence from a study by scientists in Canada who found that short term high-intensity interval training (HIT) can deliver in significantly less time the same health benefits as moderate long term "endurance" training... (Source: Diabetes News From Medical News Today)
Bone marrow cells produce nerve growth factor and promote angiogenesis around transplanted islets.
CONCLUSION: Bone marrow cells produce NGF and promote angiogenesis. Islet co-transplantation with bone marrow is associated with improvement of islet graft function. PMID: 20222164 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Microalbuminuria in hepatitis C-genotype 4: Effect of pegylated interferon and ribavirin.
CONCLUSION: HCV affected the development of microalbuminuria independent of diabetes or cryoglobulinemia. Combination therapy of pegylated interferon-ribavirin had a positive effect in reducing microalbuminuria. PMID: 20222166 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
In vitro activity of tigecycline against patient isolates collected during phase 3 clinical trials for diabetic foot infections
Abstract: The in vitro activity of tigecycline and comparative antimicrobial agents was evaluated against 1828 primary baseline pathogens isolated from 844 patients enrolled in the phase 3 clinical trials investigating the efficacy of tigecycline in diabetic foot infection (DFI). The trials were global, enrolling patients in 30 countries. Tigecycline was active against the most prevalent pathogens in DFI, including Gram-positive and Gram-negative isolates of both aerobic and anaerobic bacteria with 95% of MICs ?2 ?g/mL for the entire collection. The spectrum of activity of tigecycline included important pathogens for DFI, such as Staphylococcus aureus, Enterococcus faecalis, Streptococcus agalactiae, Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, and Bacteroides fragilis...
Antepartum and Intrapartum Risk Factors for Neonatal Encephalopathy at Term
In conclusion, 44% of cases of NE following term deliveries can be attributed to a combination of antepartum and intrapartum variables.[...]© Thieme Medical PublishersGet connected:Table of contents | Abstract | Full text (Source: American Journal of Perinatology)
Carrot-And-Stick Health Plans Aim to Cut Costs
Kaiser Health News article tells how workers at a Portland, Ore., steel mill soon will be able to pick a new type of insurance that offers free care for some illnesses, such as diabetes or depression, but requires hefty extra fees for treatments deemed overused, including knee replacements, hysterectomies and heart bypass surgery. (Source: News stories via the Rural Assistance Center)
Chapter 7 - Zygomycosis
This article describes the general characteristics of pulmonary zygomycosis, emphasizing laboratory diagnosis, and illustrates the morphology of some lesions. (Source: Jornal Brasileiro de Pneumologia)
Acute renal dysfunction following hip fracture
Abstract: We investigated the incidence, risk factors and outcome of acute renal dysfunction (ARD) in patients with a fractured neck of femur.170 consecutive patients were prospectively included in the Scottish Hip Fracture Audit database and retrospectively analysed. Historically, lack of consensus definition has hindered accurate reporting of ARD. ARD was defined using the ?RIFLE? criteria.27 patients (16%) developed ARD. Risk factors were male sex, vascular disease, hypertension, diabetes, chronic kidney disease and pre-morbid use of nephrotoxic medications (p (Source: Injury)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Chemical and Immunochemical Detection of 8-Halogenated Deoxyguanosines at Early Stage Inflammation [Cell Biology]
Myeloperoxidase (MPO) generates reactive halogenating species that can modify DNA. The aim of this study was to investigate the formation of 8-halogenated 2'-deoxyguanosines (8- halo-dGs) during inflammatory events. 8-Bromo-2'-dG (8-BrdG) and 8-chloro-2'-dG (8-CldG) were generated by treatment of MPO with hydrogen peroxide at physiological concentrations of Cl– and Br–. The formation of 8-halo-dGs with other oxidative stress biomarkers in lipopolysaccharide-treated rats was assessed by liquid chromatography tandem mass spectrometry and immunohistochemistry using a novel monoclonal antibody (mAb8B3) to 8-BrdG-conjugated keyhole limpet hemocyanin. The antibody recognized both 8-BrdG and 8-CldG. In the liver of lipopolysaccharide-treated rats, immunostaining for 8-halo-dGs, haloge...
Role of Calcium-independent Phospholipase A2{beta} in High Glucose-induced Activation of RhoA, Rho Kinase, and CPI-17 in Cultured Vascular Smooth Muscle Cells and Vascular Smooth Muscle Hypercontractility in Diabetic Animals [Signal Transduction]
Previous studies suggest that high glucose-induced RhoA/Rho kinase/CPI-17 activation is involved in diabetes-associated vascular smooth muscle hypercontractility. However, the upstream signaling that links high glucose and RhoA/Rho kinase/CPI-17 activation is unknown. Here we report that calcium-independent phospholipase A2β (iPLA2β) is required for high glucose-induced RhoA/Rho kinase/CPI-17 activation and thereby contributes to diabetes-associated vascular smooth muscle hypercontractility. We demonstrate that high glucose increases iPLA2β mRNA, protein, and iPLA2 activity in a time-dependent manner. Protein kinase C is involved in high glucose-induced iPLA2β protein up-regulation. Inhibiting iPLA2β activity with bromoenol lactone or preventing its expression by g...
Switch to insulin therapy does not reduce rate of UTIs in Type 2 diabetics
There is no evidence that switching from oral treatment to insulin therapy reduces the high rate of urinary tract infections in patients with Type 2 diabetes, say researchers. (Source: MedWire News - Diabetes)
Better to Start Metformin Early (CME/CE, with audio)
For newly diagnosed type 2 diabetes, waiting until lifestyle measures fail before starting metformin may jeopardize the long-term efficacy of the drug, a large clinical database analysis showed. (Source: MedPage Today Primary Care)
Mimetics of hormetic agents: stress-resistance triggers.
Authors: Sonneborn JS Mimetics of hormetic agents offer a novel approach to adjust dose to minimize the risk of toxic response, and maximize the benefit of induction of at least partial physiological conditioning. Nature selected and preserved those organisms and triggers that promote tolerance to stress. The induced tolerance can serve to resist that challenge and can repair previous age, disease, and trauma damage as well to provide a more youthful response to other stresses. The associated physiological conditioning may include youthful restoration of DNA repair, resistance to oxidizing pollutants, protein structure and function repair, improved immunity, tissue remodeling, adjustments in central and peripheral nervous systems, and altered metabolism. By elucidating common pathways ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Problem of immortal time bias in cohort studies: example using statins for preventing progression of diabetes
(Source: BMJ Online First)
Acute exacerbation impairs endothelial function in patients with chronic obstructive pulmonary disease.
CONCLUSION: Acute COPD exacerbation is associated with worsening endothelial function, increasing the risk for cardiovascular morbidity. PMID: 20215835 [PubMed - as supplied by publisher] (Source: Turk Kardiyoloji Dernegi arsivi)
Survey: Employers Plan To Shift More Health Costs To Workers
News outlets report on new trends in health insurance for employers. The Washington Post: "Most big employers plan to shift a larger share of health-care costs to their workers next year, according to a survey to be released Thursday. ... (Source: Diabetes News From Medical News Today)
Growth Of Chronic Kidney Disease Highlights Need For Early Detection, Greater Knowledge Of Treatment Options
As the incidence of diabetes and hypertension continues to grow worldwide - and increasing numbers of patients progressing to kidney disease and kidney failure place a financial strain on public health systems - the need for early patient education about kidney disease and treatment options, including home-based treatments, has become critical... (Source: Hypertension News From Medical News Today)
Growth Of Chronic Kidney Disease Highlights Need For Early Detection, Greater Knowledge Of Treatment Options
As the incidence of diabetes and hypertension continues to grow worldwide - and increasing numbers of patients progressing to kidney disease and kidney failure place a financial strain on public health systems - the need for early patient education about kidney disease and treatment options, including home-based treatments, has become critical. More than 240 million people have diabetes and this figure is projected to rise to 380 million by 20251. In the United States alone, 17.9 million have been diagnosed with diabetes resulting in medical and indirect costs (e.g... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Access Pharmaceuticals Reports Significant Oral Bioavailability Of Cobalamin(TM) Oral Insulin In Additional Studies
ACCESS PHARMACEUTICALS, INC. (OTC Bulletin Board: ACCP) announced that it has received reports of significant bioavailability of orally delivered insulin in two independently-conducted animal studies. The studies, which confirm earlier findings, were performed as part of on-going work with commercial collaborators that are evaluating Access' Cobalamin? Oral Drug Delivery Technology... (Source: Health News from Medical News Today)
New Alterations Found In Young Adults With Type 2 Diabetes
Diet and aerobic exercise are highly effective for the treatment of type 2 diabetes, but not for obese subjects that have developed the disease when very young. A study at the Institute for Research in Biomedicine (IRB Barcelona) and Trinity College in Dublin demonstrates that obese subjects between 18 and 25 years of age carry mitochondrial proteins and genes that work abnormally and that these anomalies contribute to generating insulin resistance and a reduced response to physical exercise... (Source: Health News from Medical News Today)
Access Pharmaceuticals Reports Significant Oral Bioavailability Of Cobalamin(TM) Oral Insulin In Additional Studies
ACCESS PHARMACEUTICALS, INC. (OTC Bulletin Board: ACCP) announced that it has received reports of significant bioavailability of orally delivered insulin in two independently-conducted animal studies. The studies, which confirm earlier findings, were performed as part of on-going work with commercial collaborators that are evaluating Access' Cobalamin? Oral Drug Delivery Technology... (Source: Diabetes News From Medical News Today)
New Alterations Found In Young Adults With Type 2 Diabetes
Diet and aerobic exercise are highly effective for the treatment of type 2 diabetes, but not for obese subjects that have developed the disease when very young... (Source: Diabetes News From Medical News Today)
Africa: Non Communicable Diseases Recognised As Major Cause of Premature Deaths in Developing Countries
Non-communicable diseases (NCDs), such as heart diseases, diabetes, cancer and respiratory diseases account for approximately 60 percent of deaths worldwide. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Australian Health Insurer NIB and Navigenics Team Up to Offer Cut-Rate Genetic Testing to NIB Customers
Australian patients are using an American clinical pathology laboratory for their genetic testing needs It?s a half-price sale of genetic clinical laboratory tests for 5,000 customers of Australian health insurer NIB. NIB wants to encourage its beneficiaries to screen themselves to identify their genetic tendencies for such conditions as heart disease, diabetes, some cancers, and [...] (Source: Dark Daily)
Epidemic of Vitamin D deficiency sweeping the world
(NaturalNews) There is an epidemic of vitamin D deficiency sweeping across our modern world, and it's an epidemic of such depth and seriousness that it makes the H1N1 swine flu epidemic look like a case of the sniffles by comparison. Vitamin D deficiency is not only alarmingly widespread, it's also a root cause of many other serious diseases such as cancer, diabetes, osteoporosis and heart disease.A new study published in the March, 2010 issue of the Journal of Clinical Endocrinology and Metabolism found that a jaw-dropping 59 percent of the population is vitamin D deficient. In addition, nearly 25 percent of the study subjects were found to have extremely low levels of vitamin D.Lead author of the study, Dr. Richard Kremer at the McGill University Health Center, said "Abnormal levels of v...
Vitamin D Improves Insulin Sensitivity, Helps Prevent Diabetes
(NaturalNews) High-dose vitamin D supplements may help increase the body's sensitivity to the blood sugar-regulating hormone insulin, thus reducing the risk of diabetes, researchers have found.Insulin resistance (or insensitivity) occurs when the body's tissues stop responding as strongly to the presence of insulin. As a consequence, the cells uptake less sugar from the bloodstream, producing the elevated glucose levels characteristic of diabetes. In the current study, conducted by researchers from Massey University and published in the British Journal of Nutrition, researchers randomly assigned 81 South Asian women between the ages of 23 and 68 to take either a placebo or 4,000 IU of vitamin D once per day. All participants suffered from insulin sensitivity at the start of the study, but ...
Cholesterol
Title: CholesterolCategory: Diseases and ConditionsCreated: 12/31/1997Last Editorial Review: 3/12/2010 (Source: MedicineNet Diabetes General)
Body's Response to Foods' Smell, Taste Could Be Diabetes Risk Factor
Title: Body's Response to Foods' Smell, Taste Could Be Diabetes Risk FactorCategory: Health NewsCreated: 3/11/2010 2:10:00 PMLast Editorial Review: 3/12/2010 (Source: MedicineNet Diabetes General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Medicine's Future Could Lie in Each Patient's Genome
Title: Medicine's Future Could Lie in Each Patient's GenomeCategory: Health NewsCreated: 3/11/2010 4:10:00 PMLast Editorial Review: 3/12/2010 (Source: MedicineNet Diabetes General)
Body's Response to Foods' Smell, Taste Could Be Diabetes Risk Factor
Title: Body's Response to Foods' Smell, Taste Could Be Diabetes Risk FactorCategory: Health NewsCreated: 3/11/2010 2:10:00 PMLast Editorial Review: 3/12/2010 (Source: MedicineNet Senior Health General)
Exercising just got easier for busy people, study shows
(McMaster University) Researchers have found that interval training does not have to be "all out" to be effective in helping reduce the risk of such diseases at Type 2 diabetes. (Source: EurekAlert! - Social and Behavioral Science)
Asymmetric Large-for-Gestational-Age Infants of Type 1 Diabetic Women: Morbidity and Abdominal Growth
Amer J PerinatolDOI: 10.1055/s-0030-1249362ABSTRACTWe sought to examine neonatal morbidity in four groups of offspring (asymmetric large for gestational age [LGA], symmetric LGA, asymmetric non-LGA, symmetric non-LGA) exposed in utero to maternal type 1 diabetes, and the association between rate of fetal abdominal circumference growth and asymmetric LGA. We performed a secondary analysis of 302 singleton pregnancies. Neonatal morbidity (respiratory distress syndrome, polycythemia, hypoglycemia, hyperbilirubinemia, acidosis, and composite morbidity [any of the five]) was assessed. Serial ultrasound examinations after 20 weeks' gestation were available for 35 fetuses. Logistic regression and general linear mixed modeling were used for analysis. Asymmetric LGA infants had 3.5-, 2.2-, and 3.2-...
Diabetes Link to Eating Disorders
Diabetics, under the gun to better manage their disease by controlling their food intake and weight, may find themselves in the sticky wicket of needing treatment that makes them hungry, researchers said. (Source: Disabled World)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Glycemic index diet: A helpful tool for diabetes?
Some people with diabetes use the glycemic index (GI) as a guide in selecting foods. (Source: MayoClinic.com - Ask a Specialist)
Diabetes and Cognitive Decline: Investigating the Potential Influence of Factors Related to Health Disparities
Discussion: Findings suggest that factors related to health disparities may influence cognitive outcomes among older adults with diabetes. (Source: Journal of Aging and Health)
[Viewpoint] The role of academic health science systems in the transformation of medicine
The challenges facing the health of communities around the world are unprecedented, and the data are all too familiar. For 5 billion people living in developing countries, environmental factors and inadequacies in hygiene, economic development, and health-care access are the main causes of shortened life expectancies. Improvements in health status, including reductions in infant mortality and declining incidence of infectious diseases, are being met by the new epidemics of obesity, diabetes mellitus, and cardiovascular disease. (Source: LANCET)
Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats.
Conclusion: Excessive dietary fat and/or increased levels of luminal bile juice, but not genetic obesity, are responsible for the increase in small intestinal permeability resulting from the suppression of TJ protein expression. (Source: Nutrition & Metabolism)
Use of pegaptanib for recurrent and non-clearing vitreous haemorrhage in proliferative diabetic retinopathy
Authors: D Hornan, N Edmeades, R Krishnan, J Khan & J Lochhead (Source: Eye)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)
Conclusion: Mutations in INS can be a rare cause of MODY and we conclude that screening for mutations in INS should be recommended in MODYX patients. (Source: BMC Medical Genetics - Latest articles)
Clinical Trial Summary: Assessment on the Prevention of Progression by Rosiglitazone on Atherosclerosis in Diabetes Patients With Cardiovascular History (APPROACH)
The goal of the trial was to evaluate treatment with rosiglitazone compared with glipizide among patients with type 2 diabetes. (Source: Cardiosource)
Age influences glucose handling in acute phase of STEMI
Older patients have higher glucose levels and worse glycemic control in the early phase of ST-elevation myocardial infarction than younger patients, although insulin resistance does not vary by age, Italian researchers have shown. (Source: MedWire News - Diabetes)
Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease
Previous studies have reported the association between type 2 diabetes mellitus (DM2) and hepatocellular carcinoma (HCC). To explore the relationships among DM2, antidiabetic therapy and HCC risk. We recruited 610 HCC patients compared with 618 matched cirrhotic patients and 1696 Controls. The odds ratio (OR) for HCC in diabetic subjects treated with insulin, sulphonylureas and metformin was calculated. DM2 prevalence was 31.2% in HCC, 23.3% in cirrhotic patients and 12.7% in Controls (P (Source: Liver International)
Diabetic Nephropathy Classification Developed
A new consensus on the classification of type 1 and type 2 diabetes-related nephropathy, dividing diabetic nephropathy into four hierarchical glomerular lesions with varying degrees of severity, may aid international clinical practice, according to an article published online Feb. 18 in the Journal of the American Society of Nephrology. (Source: Modern Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Leptin Shows Advantages Over Insulin in Type 1 Diabetes
The ability of leptin to restore hemoglobin A1c to normal in mice with diabetes (along with its additional benefits relating to body fat and cholesterol) suggests that the hormone may have a role in treating type 1 diabetes mellitus in humans, and may have both short- and long-term advantages over insulin monotherapy, according to research published online March 1 in the Proceedings of the National Academy of Sciences. (Source: Modern Medicine)
Molecular mechanisms of enhanced wound healing by copper oxide-impregnated dressings
Copper plays a key role in angiogenesis and in the synthesis and stabilization of extracellular matrix skin proteins, which are critical processes of skin formation. We hypothesized that introducing copper into wound dressings would enhance wound repair. Application of wound dressings containing copper oxide to wounds inflicted in genetically engineered diabetic mice (C57BL/KsOlaHsd-Leprdb) resulted in increased gene and in situ up-regulation of proangiogenic factors (e.g., placental growth factor, hypoxia-inducible factor-1 alpha, and vascular endothelial growth factor), increased blood vessel formation (p (Source: Wound Repair and Regeneration)
Teaching energy metabolism using scientific articles
This work describes the use of a virtual learning environment (VLE) applied to the biochemistry class for undergraduate, first-year medical students at the Federal University of Rio de Janeiro. The course focused on the integration of energy metabolism, exploring metabolic adaptations in different physiological or pathological states such as starvation, diabetes, and exercise. The VLE was designed to combine online activities with traditional course content and presented guided inquiry-based activities to assist in the use of original scientific articles as educational resources. Based on the analysis of a semi-open questionnaire, the results provided evidence that the VLE encouraged students' engagement in activities and improved feedback. The results also suggested that guided inquiry-ba...
Oxidative and Nitrosative Stress and Progression of Diabetic Nephropathy in Type 2 Diabetes
Am J Nephrol 2010;31:342–352 (DOI:10.1159/000297290) (Source: Karger Publishers)
Big first trimester weight gain ups diabetes risk
NEW YORK (Reuters Health) - Women who gain weight too quickly during the first three months of pregnancy are more prone to develop pregnancy-related diabetes, new research shows. (Source: Reuters: Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Big First Trimester Weight Gain Ups Diabetes Risk
Women who gain weight too quickly during the first three months of pregnancy are more prone to develop pregnancy-related diabetes, new research shows.Source: Reuters Health Related MedlinePlus Page: Diabetes and Pregnancy (Source: MedlinePlus Health News)
Comorbid Diabetes and Depression Increase Dementia Risk
Patients with diabetes and major depression have a markedly increased risk of developing dementia compared with their counterparts with diabetes alone. Medscape Medical News (Source: Medscape Today Headlines)
FDA Says No "Clear Connection" Between Bisphosphonate Use and Femur Fracture Risk
FDA Says No "Clear Connection" Between Bisphosphonates, Femur Fracture Risk Medscape Medical News (Source: Medscape Today Headlines)
Body's Response to Foods' Smell, Taste Could Be Diabetes Risk Factor
A gene mutation could trigger key insulin reaction in some, researchers say Source: HealthDay Related MedlinePlus Pages: Diabetes, Genes and Gene Therapy, Taste and Smell Disorders (Source: MedlinePlus Health News)
Metabolic disease prevention and suppression of fat accumulation by Salacia reticulata
In this study, we attempted to clarify the antiobesity mechanism and the safety of S. reticulata in vivo and in vitro. We gave ordinary MF feed, alone or mixed with S. reticulata (0.3 or 1.0%), to Tsumura Suzuki obesity diabetes (TSOD) mice (spontaneous obese type II diabetes model mice) and Tsumura Suzuki non-obese (TSNO) mice (the corresponding reference animals), ad libitum for 2 months. As compared with the TSNO control mice, the TSOD control mice became obese due to fat accumulation and developed various signs of metabolic diseases. The TSOD mouse group receiving S. reticulata showed the following effects: suppression of body weight increase and fat accumulation, alleviation of abnormal lipid metabolism and abnormal glucose tolerance, and suppression of intrahepatic fat accu...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Diagnostic and prognostic testing to evaluate coronary artery disease in patients with diabetes mellitus
Abstract  Coronary artery disease (CAD) continues to be the most common cause of morbidity and mortality in patients with diabetes mellitus (DM). In recent years, the strategies for treatment of CAD in DM have undergone much evolution. Currently, all patients with DM, regardless of symptoms or diagnosed CAD, are treated aggressively for CAD risk factor reduction. In this clinical climate, the ability to specifically identify patients with disease that will benefit from more aggressive and invasive therapies remains a challenge. In this article we review the current literature on diagnostic and prognostic utility of conventional non-invasive modalities for assessment of CAD in patients with DM, as well as on novel and emerging methods for CAD risk stratification. Content...
Pregnancy characteristics and maternal breast cancer risk: a review of the epidemiologic literature
Abstract  The short- and long-term effects of pregnancy on breast cancer risk are well documented. Insight into potential biological mechanisms for these associations may be gained by studying breast cancer risk and pregnancy characteristics (e.g., preeclampsia, twining), which may reflect hormone levels during pregnancy. To date, no review has synthesized the published literature for pregnancy characteristics and maternal breast cancer using systematic search methods. We conducted a systematic search to identify all published studies. Using PUBMED (to 31 July 2009), 42 relevant articles were identified. Several studies suggest that multiple births may be associated with a lowered breast cancer risk of about 10?30%, but results were inconsistent across 18 studies. The maj...
Utilities and disutilities for attributes of injectable treatments for type 2 diabetes
Discussion  The three injection attributes were associated with small utility shifts in the expected directions. Dose frequency appears to be the most important of the three attributes from the patients? perspective. The vignette-based SG approach was feasible and useful for assessing added utility or disutility of injection-related attributes associated with treatments for type 2 diabetes. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s10198-010-0224-8Authors Kristina S. Boye, Eli Lilly and Company Indianapolis IN USALouis S. Matza, United BioSource Corporation Center for Health Outcomes Research 7101 Wisconsin Avenue, Suite 600 Bethesda MD 20814 USAKimberly N. Walter, United BioSource Corporation Center for Health Outcomes Research 7101 Wisconsi...
Enhanced expression of naofen in kidney of streptozotocin-induced diabetic rats: possible correlation to apoptosis of tubular epithelial cells
Conclusions  These data suggest that naofen expression may be upregulated by hyperglycemia, with possible correlation to apoptosis of tubular epithelial cells and thereby to diabetic nephropathy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10157-010-0276-1Authors Yuko Sato, Aichi Medical University School of Medicine Department of Anesthesiology Nagakute Aichi-gun Aichi 480-1195 JapanGuo-Gang Feng, Aichi Medical University School of Medicine Department of Pharmacology Nagakute Aichi-gun Aichi 480-1195 JapanLei Huang, Aichi Medical University School of Medicine Department of Pharmacology Nagakute Aichi-gun Aichi 480-1195 JapanJun-Hua Fan, Nagoya University Graduate School of Medicine Department of Gastroenterology 65 Tsuruma-cho, Showa-ku Nagoya A...
Two single descriptors of endothelial polymegethism and pleomorphism
Conclusions  Two single quantitative parameters of endothelial polymegethism and pleomorphism (POLi and PLEi respectively) have been derived from the data obtained with a commercial non-contact specular microscope. These parameters have been demonstrated to identify differences between the corneal endothelium of diabetic and non-diabetic patients. Content Type Journal ArticleCategory CorneaDOI 10.1007/s00417-010-1337-6Authors Jose Manuel González-Méijome, University of Minho Clinical & Experimental Optometry Research Lab, Department of Physics (Optometry), School of Sciences Campus de Gualtar 4710-057 Braga PortugalJorge Jorge, University of Minho Clinical & Experimental Optometry Research Lab, Department of Physics (Optometry), School of Sciences Campus de Gualtar...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Cholesterol, Diabetes Medications Top List of Prescription Drug Expenses for Medicare Recipients
Metabolic agents make up nearly one quarter of all purchases by those aged 65 years and older. Medscape Medical News (Source: Medscape Today Headlines)
Long-Acting Insulin Analogs May up Risk of Diabetic Ketoacidosis in Children
Use of insulin glargine or detemir rather than NPH insulin does not reduce the risk of ketoacidosis in children and adolescents with type 1 diabetes, and in fact may increase the risk, a new study shows. Reuters Health Information (Source: Medscape Diabetes Headlines)
Overview on practices in thalassemia intermedia management aiming for lowering complication rates across a region of endemicity: the OPTIMAL CARE study
This study provides evidence that calls for prospective evaluation of the roles of transfusion, iron chelation, and hydroxyurea therapy in TI patients. (Source: Blood)
Adherence Studies in Adolescents with Chronic Kidney or Urologic Diseases, or Diabetes (R01)
Funding Opportunity Number: RFA-DK-10-004 Opportunity Category: DiscretionaryFunding Instrument Type: GrantCategory of Funding Activity: Food and NutritionHealthCFDA Number: 93.847Eligible Applicants State governmentsCounty governmentsCity or township governmentsSpecial district governmentsIndependent school districtsPublic and State controlled institutions of higher educationNative American tribal governments (Federally recognized)Public housing authorities/Indian housing authoritiesNative American tribal organizations (other than Federally recognized tribal governments)Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationNonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher educationPrivate instit...
World Kidney Day Podcast
The focus on diabetic kidney disease for World Kidney Day 2010 brings awareness of the magnitude of the problem and ramifications for global health for people with diabetes and kidney disease. It is therefore time to act and act urgently. It is time for strategies that prevent diabetes and its sequelae. It is time for programs for health care workers to diagnose and treat people with diabetic kidney disease. It is time for governments to pass legislation to enable the diabetes pandemic to be controlled. After all, diabetic kidney disease, like the epidemics of infectious diseases that have long dominated public health agendas, is potentially preventable. Indeed, March 11, 2010 is time to act on diabetic kidney disease and to commit to sustaining that action long after World Kidney Day. Li...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
2009 H1N1 Influenza and its Impact on People with Chronic Medical Conditions: Questions and Answers
The January 12, 2010 National Influenza Vaccination Week Webinar featured Dr. Nicole Lurie with the US Department of Health and Human Services; Dr. Anthony Fiore with Centers for Disease Control and Prevention; Dr. Otis Webb Brawley with American Cancer Society; Christine Tobin with American Diabetes Association; and Mary Partridge with the American Lung Association. (Source: PandemicFlu.gov RSS Feed for News Releases)
Metabolic Meds Top Medicare Drug Spending
Metabolic drugs (MedPage Today) -- namely cholesterol and diabetes meds -- account for the greatest Medicare prescription expenses, researchers say. (Source: MedPage Today Public Health)
Protect Your Kidneys by Controlling Diabetes and High Blood Pressure
Source: Centers for Disease Control and Prevention Related MedlinePlus Pages: Diabetic Kidney Problems, Kidney Diseases (Source: MedlinePlus Health News)
Foods high in meat and fat confer increased risk for diabetes in all ethnic groups
Foods high in meat and fat appear to confer an increased risk for diabetes in all ethnic groups, whereas the effects of other dietary patterns vary by gender and ethnicity, say US researchers. (Source: MedWire News - Diabetes)
Descending Necrotising Mediastinitis, A Fatal Disease to Keep in Mind
We report an unusual case of primary retropharyngeal abscess complicated by descending necrotising mediastinitis and bilateral empyema in a 56-year-old diabetic man. The diagnosis of descending necrotising mediastinitis (DNM) was established by the characteristic findings on computed tomography. The patient was treated by cervicotomy and staged bilateral posterolateral thoracotomy. (Source: Heart, Lung & Circulation)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Impact of Chronic Kidney Disease on Platelet Function Profiles in Diabetes Mellitus Patients With Coronary Artery Disease Taking Dual Antiplatelet Therapy
Conclusions: In DM patients with coronary artery disease taking maintenance aspirin and clopidogrel therapy, impaired renal function is associated with reduced clopidogrel-induced antiplatelet effects and a greater prevalence of HPPR. (Source: Journal of the American College of Cardiology)
Determinants of Coronary Calcium Conversion Among Patients With a Normal Coronary Calcium Scan: What Is the ?Warranty Period? for Remaining Normal?
Conclusions: Among individuals with CAC = 0, conversion to CAC >0 is nonlinear and occurs at low frequency before 4 years. No clinical factor seems to mandate earlier repeat CAC scanning. (Source: Journal of the American College of Cardiology)
Single and unhappily married men are at 64% higher risk of dying from stroke
Men who were single in the 1960s were 64% more likely to suffer a fatal stroke over the next three decades than their married counterparts.The risk of fatal stroke was also 64% higher in men who reported dissatisfaction with their marriages than in men who rated their marriages as successful.That figure is comparable to the risk of fatal stroke faced by men with diabetes.References:Single Men Have Higher Risk of Stroke. WebMD.Image source: CT scan slice of the brain showing a right-hemispheric ischemic stroke (left side of image). Wikipedia, GNU Free Documentation License. Posted at Clinical Cases and Images. Stay updated and subscribe, follow on Twitter and Buzz, and connect on Facebook. (Source: Clinical Cases and Images)
Medical care costs among patients with established cardiovascular disease.
CONCLUSIONS: The economic burden of providing care to patients with CVD may be substantially greater than current American Heart Association estimates. Although several comorbid conditions undoubtedly contribute to these costs, avoidance of secondary CVD hospitalization may be the key to substantially reducing healthcare consumption. PMID: 20205493 [PubMed - in process] (Source: The American Journal of Managed Care)
Diabetic kidney disease: act now or pay later.
Authors: Atkins RC, Zimmet P PMID: 20213919 [PubMed - in process] (Source: American Journal of Nephrology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
New cholesterol drug tested
Conclusion This is an important and well-conducted trial, which has demonstrated the potential of a drug, eprotirome, to lower cholesterol levels. However, conclusions about the effects of this drug should not be made too prematurely and much further research is needed: So far, use of the drug alone has not been compared to statin treatment. In this trial eprotirome or inactive placebo was only ever given in addition to people?s long-term statins. Therefore no comparison of cholesterol-lowering effect of each of the treatments alone can be made. Only a small number of people were included in the trial: 47 on the 25microgram dose, 46 on 50micrograms, and 44 on the 100microgram dose of eprotirome. These groups of participants are too small to draw any conclusions on the safety or eff...
Agency For Healthcare Research And Quality News And Numbers: High Cholesterol, Diabetes Lead Drug Spending For The Elderly
Purchases of cholesterol and diabetes prescription drugs by elderly Medicare beneficiaries reached nearly $19 billion in 2007 - about one-fourth of the approximately $82 billion spent for medications for the elderly, according to the latest AHRQ News and Numbers... (Source: Cholesterol News From Medical News Today)
The American Diabetes Association Encourages Community Organizations To Join The Movement To Stop Diabetes
The American Diabetes Association announced today their efforts to further engage community organizations across the country in raising awareness about the seriousness of diabetes and its complications through the Association's Stop Diabetes movement. The American Diabetes Association is rolling out a Stop Diabetes Community Outreach Toolkit to help community and faith-based organizations, health clinics, libraries, hospitals, fraternal groups and corporations raise awareness of diabetes risk factors among their constituents... (Source: Health News from Medical News Today)
Agency For Healthcare Research And Quality News And Numbers: High Cholesterol, Diabetes Lead Drug Spending For The Elderly
Purchases of cholesterol and diabetes prescription drugs by elderly Medicare beneficiaries reached nearly $19 billion in 2007 - about one-fourth of the approximately $82 billion spent for medications for the elderly, according to the latest AHRQ News and Numbers. Metabolic drugs, which are used to lower cholesterol levels, keep diabetes under control and for weight and thyroid problems, topped the list of the five leading categories of drugs purchased by the elderly... (Source: Health News from Medical News Today)
Glycated Hemoglobin Tests See Increasing Use
Glycated hemoglobin (HbA1c) testing is one of the success stories of point-of-care diagnostics, and an area that will experience higher growth rates than other POC tests as a result of expert recommendations, new cases and booming mail-in test sales, according to the new report "Point-of-care Diagnostics 2010 and Beyond: Rapid Testing at a Crossroads," by healthcare market research publisher Kalorama Information. The test measures glucose attached to the blood protein hemoglobin, a well-established analyte related to the long-term evaluation of blood sugar control... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
The American Diabetes Association Encourages Community Organizations To Join The Movement To Stop Diabetes
The American Diabetes Association announced today their efforts to further engage community organizations across the country in raising awareness about the seriousness of diabetes and its complications through the Association's Stop Diabetes movement... (Source: Diabetes News From Medical News Today)
Glycated Hemoglobin Tests See Increasing Use
Glycated hemoglobin (HbA1c) testing is one of the success stories of point-of-care diagnostics, and an area that will experience higher growth rates than other POC tests as a result of expert recommendations, new cases and booming mail-in test sales, according to the new report "Point-of-care Diagnostics 2010 and Beyond: Rapid Testing at a Crossroads," by healthcare market rese... (Source: Diabetes News From Medical News Today)
Recent Studies Link Obesity To Food Allergies
First Lady Michelle Obama's "Let's Move" Campaign tells us that about 32 percent of children and teens (or 25 million) are obese or overweight. It revealed those extra pounds put them at greater risk of developing debilitating and costly diseases including diabetes, high blood pressure and high cholesterol and may also cause them to lead a two to five year shorter life than their parents... (Source: Health News from Medical News Today)
Recent Studies Link Obesity To Food Allergies
First Lady Michelle Obama's "Let's Move" Campaign tells us that about 32 percent of children and teens (or 25 million) are obese or overweight. It revealed those extra pounds put them at greater risk of developing debilitating and costly diseases including diabetes, high blood pressure and high cholesterol and may also cause them to lead a two to five year shorter life than their parents... (Source: Allergy News From Medical News Today)
No mortality benefit in reducing HbA1c below 9%
There is little to gain in terms of reduced mortality from continually lowering HbA1c targets in patients with type 2 diabetes, a Dutch study has concluded. (Source: Pulse)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Revascularization for coronary artery disease in diabetes mellitus: Angioplasty, stents and coronary artery bypass grafting
Abstract  Patients with diabetes mellitus (DM) are prone to a diffuse and rapidly progressive form of atherosclerosis, which increases their likelihood of requiring revascularization. However, the unique pathophysiology of atherosclerosis in patients with DM modifies the response to arterial injury, with profound clinical consequences for patients undergoing percutaneous coronary intervention (PCI). Multiple studies have shown that DM is a strong risk factor for restenosis following successful balloon angioplasty or coronary stenting, with greater need for repeat revascularization and inferior clinical outcomes. Early data suggest that drug eluting stents reduce restenosis rates and the need for repeat revascularization irrespective of the diabetic state and with no signifi...
Clinical outcomes in diabetic and non-diabetic patients with drug-eluting stents: results from the first phase of the prospective multicenter German DES.DE registry
Conclusion  Data collected in DES.DE revealed that despite the use of DES the risk of myocardial infarction, death, and thrombotic events remains higher in diabetic patients. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00392-010-0136-8Authors Ibrahim Akin, University Hospital Rostock, Rostock School of Medicine Divisions of Cardiology, Pulmonology, Department of Internal Medicine I, Intensive Care Unit Ernst-Heydemann-Str. 6 18057 Rostock GermanyAlexander Bufe, University of Witten/Herdecke Department of Cardiology, Helios Clinic Wuppertal Wuppertal GermanySteffen Schneider, Heart Center Ludwigshafen Department of Cardiology Ludwigshafen GermanyHolger Reinecke, University Hospital Münster Department of Cardiology Münster GermanyLars Eckardt, Univ...
Oligodeoxynucleotide IMT504 induces a marked recovery in a streptozotocin-induced model of diabetes in rats: correlation with an early increase in the expression of nestin and neurogenin 3 progenitor cell markers
Conclusions/interpretation  IMT504 induced a marked recovery of STZ-induced diabetes that correlated with early production of progenitor cell markers, such as nestin and NGN3. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1694-zAuthors M. S. Bianchi, Institute of Biology and Experimental Medicine (IBYME-CONICET) Buenos Aires ArgentinaA. Hernando-Insúa, Immunotech Buenos Aires ArgentinaN. A. Chasseing, Institute of Biology and Experimental Medicine (IBYME-CONICET) Buenos Aires ArgentinaJ. M. Rodríguez, Fundación Pablo Cassará Buenos Aires ArgentinaF. Elías, Fundación Pablo Cassará Buenos Aires ArgentinaN. Lago, Gema Biotech Buenos Aires ArgentinaJ. Zorzopulos, Immunotech Buenos Aires ArgentinaC. Libertun, Institute of Biology and Experimenta...
Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments
Conclusions/interpretation  TETA may limit the cardiac and renal/vascular damage inflicted by diabetes through its actions to reinforce antioxidant defence mechanisms, probably acting through selective chelation of ?loosely-bound?/chelatable Cu(II). It may also improve heparan sulphate homeostasis and bolster antioxidant defence by increasing vascular extracellular superoxide dismutase activity. Urinary albumin/creatinine ratio might prove useful for monitoring TETA treatment. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1698-8Authors J. Lu, University of Auckland School of Biological Sciences, Faculty of Science Private Bag 92019 Auckland New ZealandD. Gong, University of Auckland School of Biological Sciences, Faculty of Science Private B...
Frequent napping linked to increased risk of type 2 diabetes in older adults
A study shows that frequent napping is associated with an elevated prevalence of type 2 diabetes and impaired fasting glucose in an older Chinese population. (Source: ScienceDaily Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Cardiac Catheterizations: Too Many Performed?
Title: Cardiac Catheterizations: Too Many Performed?Category: Health NewsCreated: 3/11/2010 10:14:00 AMLast Editorial Review: 3/11/2010 10:14:51 AM (Source: MedicineNet Diabetes General)
Glycemic index diet: A helpful tool for diabetes?
Some people with diabetes use the glycemic index (GI) as a guide in selecting foods. (Source: MayoClinic.com Full Feed)
New alterations found in young adults with type 2 diabetes
(Institute for Research in Biomedicine (IRB Barcelona)) Diet and aerobic exercise are highly effective for the treatment of type 2 diabetes, but not for obese subjects that have developed the disease when very young. A study at the IRB Barcelona and Trinity College in Dublin demonstrates that obese subjects between 18 and 25 years of age carry mitochondrial proteins and genes that work abnormally and that these anomalies contribute to generating insulin resistance and a reduced response to physical exercise. (Source: EurekAlert! - Medicine and Health)
Insurers Test Health Plans that Stress Patient Choices
Workers at a Portland, Ore., steel mill soon will be able to pick a new type of insurance that offers free care for some illnesses, such as diabetes or depression, but requires hefty extra fees for treatments deemed overused, including knee replacements, hysterectomies and heart bypass surgery. (Source: RWJF News Digest - Quality/Equality)
New alterations found in young adults with type 2 diabetes
Diet and aerobic exercise are highly effective for the treatment of type 2 diabetes, but not for obese subjects that have developed the disease when very young. A new study demonstrates that obese subjects between 18 and 25 years of age carry mitochondrial proteins and genes that work abnormally and that these anomalies contribute to generating insulin resistance and a reduced response to physical exercise. (Source: ScienceDaily Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Diabetes' link to eating disorders explored
(Medical College of Georgia) Diabetics, under the gun to better manage their disease by controlling their food intake and weight, may find themselves in the sticky wicket of needing treatment that makes them hungry, researchers said. (Source: EurekAlert! - Biology)
Body's anticipation of a meal can be a diabetes risk factor
(Duke University Medical Center) Alterations in our response to the taste or smell of food may be another culprit responsible for Type 2 diabetes, according to scientists at Duke University Medical Center who have identified the specific mechanism in human specimens and in mice. (Source: EurekAlert! - Medicine and Health)
Depression plus diabetes may = dementia
SEATTLE, March 10 (UPI) -- Diabetes combined with depression increases dementia risk, University of Washington researchers found. (Source: Health News - UPI.com)
Measurement of Adiponectin Production from Differentiated Metabolic Stem Cells
Horm Metab ResDOI: 10.1055/s-0030-1248304AbstractTo treat metabolic syndrome, fat tissue dysfunction should be corrected rather than controlling conventional risk factors such as hypertension, dyslipidemia, and diabetes mellitus. For this purpose, accumulating evidence suggests increasing plasma adiponectin levels can be a key treatment strategy, especially in setting of food or drug selection. Here we report that adipocyte precursors obtained from several sites of fat tissue, which we call Metabolic Stem Cells (MSC), could be used as a novel screening system to identify adiponectin enhancing drugs or food for individual patients. MSC were prepared from fat tissues collected from 29 patients. They were differentiated in cultures into mature adipocytes. The time course of adiponectin produc...
Management of dyslipidemia in people with type 2 diabetes mellitus
Abstract  Cardiovascular disease is a major complication of type 2 diabetes mellitus, and this is partly due to associated abnormalities of plasma lipid and lipoprotein metabolism. Although glycemic control improves plasma lipoprotein abnormalities and may have an independent benefit on cardiovascular risk reduction, the magnitude of this benefit is less than cholesterol lowering therapy. Current treatment guidelines for the management of dyslipidemia in people with type 2 diabetes are based on the results of cardiovascular outcome clinical trials. Primary emphasis of treatment should be on lowering LDL-C to < 100 mg/dl with statins. If cardiovascular disease is present, then high dose statins should be used, and an optional LDL-C goal < 70 is recommended. If tri...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Opposing effects of dietary sugar and saturated fat on cardiovascular risk factors and glucose metabolism in mitochondrially impaired mice
Conclusions  Taken together, our results suggest that mitochondrial dysfunction may cause sucrose to become a multifunctional cardiovascular risk factor, whereas low-sugar diets high in saturated fat may prevent weight gain without improving glucose metabolism. Content Type Journal ArticleCategory Original ContributionDOI 10.1007/s00394-010-0100-4Authors Doreen Kuhlow, University of Jena Department of Human Nutrition, Institute of Nutrition 07743 Jena GermanyKim Zarse, University of Jena Department of Human Nutrition, Institute of Nutrition 07743 Jena GermanyAnja Voigt, German Institute of Human Nutrition Potsdam-Rehbrücke Department of Clinical Nutrition 14558 Nuthetal GermanyTim J. Schulz, University of Jena Department of Human Nutrition, Institute of Nutrition 077...
Erratum to: Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 finnish adults
Content Type Journal ArticleCategory ErratumDOI 10.1007/s00125-010-1709-9Authors A. Jonsson, Lund University Department of Clinical Sciences?Diabetes and Endocrinology, CRC, Malmö University Hospital MAS Malmö SwedenF. Renström, Umeå University Hospital Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Medicine Clinic Level 4, Stair B Umeå 901 87 SwedenV. Lyssenko, Lund University Department of Clinical Sciences?Diabetes and Endocrinology, CRC, Malmö University Hospital MAS Malmö SwedenE. C. Brito, Umeå University Hospital Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Medicine Clinic Level 4, Stair B Umeå 901 87 SwedenB. Isomaa, Folkhälsan Genetic Institute Helsinki F...
Ablation of AMP-activated protein kinase ?1 and ?2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo
Conclusions/interpretation  Inhibition of AMPK activity within the beta cell is necessary, but not sufficient for stimulation of insulin secretion by glucose to occur. AMPK activation in extrapancreatic RIP2.Cre-expressing cells might also influence insulin secretion in vivo. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1692-1Authors G. Sun, Imperial College London Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Sir Alexander Fleming Building, Exhibition Road, South Kensington London SW7 2AZ UKA. I. Tarasov, Imperial College London Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Sir Alexander Fleming Bu...
ZenBio Licenses An Important Cell Line From Harvard To Drive Metabolic Disease Research
ZenBio announce that they will be a commercial source for the popular murine 3T3-L1 cell line, which has been fundamental in metabolic disease research for 30 years. Originally derived from Swiss mouse embryo tissue by Dr. Howard Green of the Department of Cell Biology at Harvard Medical School, the 3T3-L1 system has been pivotal in advancing the understanding of basic cellular mechanisms associated with diabetes, obesity and other related disorders... (Source: Health News from Medical News Today)
An observational study of type 2 diabetes within a large Australian tertiary hospital pediatric diabetes service
Conclusions: At present, T2DM in youth remains a low burden on our services. Patients with this diagnosis, however, have significant problems that present a major challenge to the development of effective management strategies. (Source: Pediatric Diabetes)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Comparison of Humalog Mix 50 with human insulin Mix 30 in type 2 diabetes patients during Ramadan
Conclusion: Changing to humalog Mix 50 during Ramadan resulted in improvement in glycaemic control without increasing the incidence of hypoglycaemia. (Source: International Journal of Clinical Practice)
Identification of bioactive compounds from flowers of black elder (Sambucus nigra L.) that activate the human peroxisome proliferator-activated receptor (PPAR) [ggr]
Obesity is one of the predisposing factors for the development of overt Type 2 diabetes (T2D). T2D is caused by a combination of insulin resistance and [bgr]-cell failure and can be treated with insulin sensitizing drugs that target the nuclear receptor peroxisome proliferator-activated receptor (PPAR) [ggr]. Extracts of elderflowers (Sambucus nigra) have been found to activate PPAR[ggr] and to stimulate insulin-dependent glucose uptake suggesting that they have a potential use in the prevention and/or treatment of insulin resistance. Bioassay-guided chromatographic fractionation of a methanol extract of elderflowers resulted in the identification of two well-known PPAR[ggr] agonists; [agr]-linolenic acid and linoleic acid as well as the flavanone naringenin. Naringenin was found to activa...
Varying recurrence rates and risk factors associated with different definitions of local recurrence in patients with surgically resected, stage I nonsmall cell lung cancer
The objective of this study was to examine the effects of different definitions of local recurrence on the reported patterns of failure and associated risk factors in patients who undergo potentially curative resection for stage I nonsmall cell lung cancer (NSCLC).The study included 306 consecutive patients who were treated from 2000 to 2005 without radiotherapy. Local recurrence was defined either as "radiation" (r-LR) (according to previously defined postoperative radiotherapy fields), including the bronchial stump, staple line, ipsilateral hilum, and ipsilateral mediastinum; or as "comprehensive" (c-LR), including the same sites plus the ipsilateral lung and contralateral mediastinal and hilar lymph nodes. All recurrences that were not classified as "local" were considered to be distal....
NHS Diabetes publishes new guidelines on the management of patients with diabetes
Source: NHS Diabetes Area: News NHS Diabetes have published a range of new publications at the Diabetes UK Annual Professional Conference (please see links below for access to the guidelines):   . Hospital management of hypoglycaemia in adults with diabetes mellitus . Joint British Diabetes Societies Inpatient Care Group: The Management of Diabetic Ketoacidosis in Adults . Safe and Effective use of Insulin in Hospitalised Patients . Emotional and Psychological Support and Care in Diabetes Report from the emotional and psychological support working group of NHS Diabetes and Diabetes UK . Self monitoring of blood glucose in non-insulin-treated Type 2 diabetes . Diabetes - put your feet first. Top tips: foot care information for people with diabetes (So...
No association between thiazolidinedione exposure and DME
Exposure to thiazolidinediones is not associated with increased risk for diabetic macular edema in patients with Type 2 diabetes, suggest study results. (Source: MedWire News - Diabetes)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Thiazolidinediones Not Linked to Diabetic Macular Edema
In patients with type 2 diabetes, thiazolidinedione exposure is not associated with an increased risk of diabetic macular edema. In addition, an intravitreous dexamethasone drug delivery system shows promise in the treatment of persistent diabetic macular edema, according to research published in the March issue of the Archives of Ophthalmology. (Source: Modern Medicine)
In Vitro Potential of Ascophyllum nodosum Phenolic Antioxidant-Mediated α-Glucosidase and α-Amylase Inhibition
This study suggests a nutraceutical potential of A. nodosum based on phytochemical antioxidant and antihyperglycemia activities. (Source: Journal of Food Science)
Diabetic macular oedema: physical, physiological and molecular factors contribute to this pathological process
Diabetic macular oedema (DMO) is an important cause of vision loss in patients with diabetes mellitus. The underlying mechanisms of DMO, on both macrocellular and microcellular levels, are discussed in this review. The pathophysiology of DMO can be described as a process whereby hyperglycaemia leads to overlapping and inter-related pathways that play a role not only in the initial vascular events, but also in the continued tissue insult that leads to chronic DMO. On a macrocellular level, DMO is believed to be in part caused by alterations in hydrostatic pressure, oxygen tension, oncotic pressure and shear stress. Three key components of the microvascular pathways include angiogenic factor expression, inflammation and oxidative stress. These molecular mediators, acting in conjunction with ...
3D-QSAR Studies on a Series of 5-Arylidine-2, 4-Thiazolidinediones as Aldose Reductase Inhibitors: A Self-Organizing Molecular Field Analysis Approach.
Authors: Thareja S, Aggarwal S, Bhardwaj TR, Kumar M Aldose Reductase (AR), the key enzyme of the polyol pathway catalyzes the reduction of glucose to sorbitol using nicotinamide adenine dinucleotide phosphate as an essential cofactor, has been demonstrated to play an important role in the pathogenesis of diabetic complications. Self Organizing Molecular Field Analysis (SOMFA), a novel three-dimensional quantitative structure activity relationship (3D-QSAR) method has been used in present case to study the correlation between the molecular properties and the aldose reductase inhibitory activities on a series of 5-arylidine-2, 4-thiazolidinedione. SOMFA calculations for both shape and electrostatic potentials were carried out. The master grid maps derived from the best model has been us...
Diamyd Medical: Diamyd US Phase III Study Well Under Way
Diamyd Medical (STO:DIAMB)(Pink Sheets:DMYDY) announces today that one hundred study participants have been included in the ongoing US Phase III study, DiaPrevent. The global Phase III program with the company's lead drug candidate Diamyd® has thereby enrolled more than 430 children newly diagnosed with type 1 diabetes in Europe and the USA. One hundred patients are now enrolled in the company's US Phase III study called DiaPrevent at 33 diabetes centers throughout the USA and more sites will be added... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Diamyd Medical: Diamyd US Phase III Study Well Under Way
Diamyd Medical (STO:DIAMB)(Pink Sheets:DMYDY) announces today that one hundred study participants have been included in the ongoing US Phase III study, DiaPrevent. The global Phase III program with the company's lead drug candidate Diamyd® has thereby enrolled more than 430 children newly diagnosed with type 1 diabetes in Europe and the USA... (Source: Diabetes News From Medical News Today)
Existence of pyogenic spondylitis in Modic type 1 change without other signs of infection: 2-year follow-up
Abstract  The relationship of Modic change to pain and inflammation remains to be unclear. Recently, some authors have reported that Modic type 1 signals are closely related to infection. However, if the patients do not have severe back pain, fever, or an abnormal blood profile, it is difficult to distinguish between common Modic change and infection. The purpose of this study was to examine the prevalence of pyogenic spondylitis in patients who showed Modic type 1 change without other signs of infection. Seventy-one patients with Modic type 1 change were evaluated (average age 55, 32 males and 39 females). X-ray and magnetic resonance imaging (MRI) were performed to investigate low-back pain and leg pain. Body temperature was measured and blood analysis (including white bl...
IL-2 and IFN-gamma in the retina of diabetic rats
Conclusions  Immunoregulatory cytokines belonging to the Th-1 group (IL-2 and IFN-gamma) were increased in the retina of experimental diabetic rats. Moreover, the nitrotyrosine formation (as an expression of increased NO production) was significantly elevated in the diabetic retina, supporting the concept of an inflammatory element in the development of diabetic retinopathy. Content Type Journal ArticleCategory Basic ScienceDOI 10.1007/s00417-009-1289-xAuthors Siv Johnsen-Soriano, Bifurcación Pio Baroja-General Avilés Fundación Oftalmológica del Mediterráneo (FOM) s/n 46015 Valencia SpainMaría Sancho-Tello, Bifurcación Pio Baroja-General Avilés Fundación Oftalmológica del Mediterráneo (FOM) s/n 46015 Valencia SpainEmma Arnal, Bifurcación Pio Baroja-Genera...
Treatment of neovascular age-related macular degeneration with a variable ranibizumab dosing regimen and one-time reduced-fluence photodynamic therapy: the TORPEDO trial at 2 years
Conclusion  Combined PDT and ranibizumab injection the same day was well tolerated in all patients. Eighty-four percent of patients had stable or improved vision at month 24. Content Type Journal ArticleCategory Retinal DisordersDOI 10.1007/s00417-009-1256-6Authors Leigh Spielberg, University Hospital Leuven Department of Ophthalmology Kapucijnenvoer 33 3000 Leuven BelgiumAnita Leys, University Hospital Leuven Department of Ophthalmology Kapucijnenvoer 33 3000 Leuven Belgium Journal Graefe's Archive for Clinical and Experimental OphthalmologyOnline ISSN 1435-702XPrint ISSN 0721-832X (Source: Graefe's Archive for Clinical and Experimental Ophthalmology)
San Antonio heart study diabetes prediction model applicable to a Middle Eastern population? Tehran glucose and lipid study
Discussion and conclusion  The American SAHS was a prediction model for diabetes with good discrimination in an Iranian target population after calibration. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00038-010-0130-yAuthors Mohammadreza Bozorgmanesh, Shahid Beheshti University of Medical Sciences Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences P.O. Box 19395-4763 Tehran Islamic Republic of IranFarzad Hadaegh, Shahid Beheshti University of Medical Sciences Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences P.O. Box 19395-4763 Tehran Islamic Republic of IranAzadeh Zabetian, Shahid Beheshti University of Medical Sciences Prevention of Metabolic Disorders Research Ce...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Role of C-Reactive Protein in Contributing to Increased Cardiovascular Risk in Metabolic Syndrome
Abstract  Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Low-grade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. This review outlines the role of high-sensitivity C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes. Content Type Journal ArticleDOI 10.1007/s11883-010-0098-3Authors Sridevi Devaraj, University of California Davis Medical Center Laboratory for Atherosclerosis and Metabolic Research 4635 2nd Avenue, Research 1 Building, Room 3000 Sacramento CA 95817 USASimona Va...
Inhibition of JAK/STAT signaling pathway prevents high-glucose-induced increase in endothelin-1 synthesis in human endothelial cells
Abstract  Emerging evidence demonstrates the involvement of endothelin-1 (ET-1) in the pathophysiology of cardiovascular disorders associated with diabetes mellitus. The molecular mechanisms accountable for the increased production of ET-1 are not completely defined. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway is an essential pathogenic mechanism leading to endothelial cell dysfunction. Our aim has been to investigate the role of JAK/STAT in the regulation of ET-1 synthesis in human endothelial cells (EAhy926 cells line). EAhy926 cells were exposed to normal (5 mM) or high (25 mM) glucose concentrations in the presence/absence of various JAK/STAT inhibitors. Using real-time polymerase chain reaction, enzyme-linked...
Treatment of Gestational Diabetes Does Not Affect Childhood BMI
While treatment of gestational diabetes markedly reduces macrosomia at birth, it does not reduce the infant's risk of a high body mass index (BMI) in early childhood. Reuters Health Information (Source: Medscape Medical News Headlines)
Thiazolidinediones Don't Cause Macular Edema: Study
Thiazolidinediones don't seem to cause macular edema in type 2 diabetics, the ACCORD Study Group reports. Reuters Health Information (Source: Medscape Medical News Headlines)
Adherence Studies in Adolescents with Chronic Kidney or Urologic Diseases, or Diabetes (R01)
Request for Applications from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP-C/EBP{alpha} in human umbilical vein endothelial cells from gestational diabetes
Conclusion The hCHOP–C/EBP complex down-regulates SLC29A1 expression in an NO-dependent manner in HUVECs from gestational diabetes. (Source: Cardiovascular Research)
Mitigating the Cardiovascular Risk of Anemia in Patients with Type 2 Diabetes and CKD: Does Darbepoetin Help? The TREAT Trial
Content Type Journal ArticleCategory Clinical Trial ReportDOI 10.1007/s11892-010-0098-2Authors Christi Hayes, State University of New York-Downstate Medical Center and Kings County Hospital Division of Endocrinology, Department of Medicine 450 Clarkson Avenue Box 50 Brooklyn NY 11203 USAAnis Alam, State University of New York-Downstate Medical Center and Kings County Hospital Division of Endocrinology, Department of Medicine 450 Clarkson Avenue Box 50 Brooklyn NY 11203 USAJulie Black-Peart, State University of New York-Downstate Medical Center and Kings County Hospital Division of Endocrinology, Department of Medicine 450 Clarkson Avenue Box 50 Brooklyn NY 11203 USASamy I. McFarlane, State University of New York-Downstate Medical Center and Kings County Hospital Division of Endocrinolo...
Insulin, Insulin Resistance, Obesity, and Cancer
Abstract  Epidemiologic studies have proposed a link between obesity, type 2 diabetes, and cancer. The pathophysiologic mechanisms involved in the development of type 2 diabetes, namely hyperinsulinemia and insulin resistance, have also been implicated in cancer development. Patients with type 2 diabetes are reported to have a worse response to cancer chemotherapy, have more complications, and have a poorer prognosis than patients with cancer without diabetes. Studies also have reported that insulin, insulin secretagogues, and metformin may have effects on tumor growth. Given the escalating worldwide prevalence of obesity and type 2 diabetes, their relationship to cancer has generated great interest and research across many fields of medicine. Content Type Journal Artic...
Usefulness of Vegetarian and Vegan Diets for Treating Type 2 Diabetes
This article reviews observational studies and intervention trials on such diets, and discusses their efficacy, nutritional adequacy, acceptability, and sustainability. Research to date has demonstrated that a low-fat, plant-based nutritional approach improves control of weight, glycemia, and cardiovascular risk. These studies have also shown that carefully planned vegan diets can be more nutritious than diets based on more conventional diet guidelines, with an acceptability that is comparable with that of other therapeutic regimens. Current intervention guidelines from professional organizations offer support for this approach. Vegetarian and vegan diets present potential advantages in managing type 2 diabetes that merit the attention of individuals with diabetes and their caregiver...
Overview of the importance of glycaemic control for cardiovascular events in the in-and out-patient setting
Abstract  Worldwide prevalence of diabetes mellitus in the adult population is increasing and when explicitly searched within specific groups of patients, as those presenting cardiovascular disease (CVD), dysglycaemia is detected in about three-quarters of the patients. Dysglycaemia alone is a major risk factor for microvascular and macrovascular complications that impair quality of life and diminish survival. The coexistence of CVD and dysglycaemia in the same individual increases its cardiovascular risk considerably. Since a significant proportion of dysglycaemic individuals develop vascular damage and the disturbed glucose metabolism remains undetected until the first cardiovascular event, there is imperative need for improved strategies for glucometabolic health assessm...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
18F-fluorodeoxyglucose positron emission tomography immediately after chemoradiotherapy predicts prognosis in patients with locoregional postoperative recurrent esophageal cancer
Conclusions  FDG-PET performed even <7 days after chemoradiotherapy predicts prognosis in patients with postoperative recurrent esophageal cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-010-0044-yAuthors Keiichi Jingu, Tohoku University School of Medicine Department of Radiation Oncology 1-1 Seiryo-machi, Aoba-ku Sendai 980-8574 JapanTomohiro Kaneta, Tohoku University School of Medicine Department of Diagnostic Radiology Sendai JapanKenji Nemoto, Yamagata University School of Medicine Department of Radiation Oncology Yamagata JapanKen Takeda, Tohoku University School of Medicine Department of Radiation Oncology 1-1 Seiryo-machi, Aoba-ku Sendai 980-8574 JapanYoshihiro Ogawa, Tohoku University School of Medicine Department of Rad...
Serum Cyfra 21.1 and galectin-3 protein levels in relation to immunohistochemical cytokeratin 19 and galectin-3 expression in patients with thyroid tumors
Conclusions  While CK19 and gal-3 are accurate as tissue markers, their serum levels could not be used as reliable markers for identification of thyroid malignancy or in thyroid cancer follow-up. On the other hand, a tendency toward higher serum levels of Cyfra 21.1 in the small number of PDTC patients examined adds weight to previous reports postulating a role for cytokeratins in predicting a high degree of malignancy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0838-3Authors Tijana I?i?, University of Belgrade Institute for the Application of Nuclear Energy, INEP Banatska 31b 11080 Zemun, Belgrade SerbiaSvetlana Savin, University of Belgrade Institute for the Application of Nuclear Energy, INEP Banatska 31b 11080 Zemun, Belgrade Ser...
L-Arginine in pregnant scleroderma patients
Abstract  Systemic sclerosis (SSc) pregnant women show a high frequency of premature births and occurrence of renal crisis. Some evidences showed the role of L-arginine in the prevention and treatment of preeclampsia. Here, we report our experience on the effect of L-arginine treatment in four consecutive SSc pregnant women. Two patients, who have planned the pregnancy, were treated with oral L-arginine; both delivered healthy babies without any prenatal complications. The other two, with high risk of pregnancy complications because of severe lung involvement and type 1 diabetes, respectively, underwent i.v. L-arginine: patient 3 had a premature delivery of a 2-kg healthy baby, while patient 4 developed preeclampsia and, at the 28th week, delivered a 1,050-g girl. The neonate...
Late mortality in pediatric patients with craniopharyngioma
Abstract  Ten year survival rates for patients with craniopharyngioma vary from 24 to 100%. A review of the database of all children diagnosed with craniopharyngioma in British Columbia (BC) revealed that several patients died >10 years after diagnosis. This retrospective study investigates the causes and timing of deaths and reports the overall survival in this population based group of patients. A chart review was conducted on all patients aged <17 years, diagnosed in BC with craniopharyngioma between 1967 and 2003. Imaging studies were reviewed by a neuroradiologist. All deaths in the province are reported to a central agency, which allowed identification of patients who died after being lost to clinical follow up. Forty-one patients were identified with ...

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