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	Losing weight may pollute the blood Weight loss releases chemical pollutants into the blood, which can stick around, increasing the risk of diabetes, cancer and dementia (Source: New Scientist - Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Diabetes education programme cost effective in UK (Source: PharmacoEconomics and Outcomes News) Concern over diabetes drug sales Concerns have been raised after a diabetes drug that was urged to be withdrawn from sale more than two months ago remains available (Source: Nursing in Practice) Erectile dysfunction common in Chinese men with Type 2 diabetes Erectile dysfunction affects three-quarters of Chinese men with Type 2 diabetes, say researchers who add that the majority of such men can be successfully treated with sildenafil citrate. (Source: MedWire News - Diabetes) The role of PPAR?in pancreatic cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus This article will review the mechanisms by which PPAR?activation acts to maintaincell function and survival in Type 2 diabetes mellitus and highlight some of the current controversies in this field. (Source: Diabetes, Obesity and Metabolism) Drug withdrawal advice unheeded A recommendation from the British Medical Journal (BMJ) to withdraw a popular diabetes drug has gone unheeded for two months despite concerns the drug may raise the risk of heart attacks (Source: Pharmacy Europe)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Gender differences in the effects of streptozotocin-induced diabetes on parasympathetic vasodilatation in the rat submandibular gland Conclusions: Parasympathetic vasodilatation in the rat submandibular gland is diminished equally in diabetic males and females. However, in males diabetes predominantly impairs PGI2- and NO-dependent vasodilatation, whereas in females the contribution of EDHF-mediated pathways are affected and NO-dependent vasodilatation is preferentially maintained. (Source: Archives of Oral Biology) Erectile dysfunction common in Chinese men with Type 2 diabetes Erectile dysfunction affects three-quarters of Chinese men with Type 2 diabetes, say researchers who add that the majority of such men can be successfully treated with sildenafil citrate. (Source: MedWire News - Hypertension) The Effect of Features of the Metabolic Syndrome on Atherosclerotic Risk in Relatively Long-Surviving Patients with Type 1 Diabetes Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders) Effect of Subcutaneous Glucose Sensor Implantation on Skin mRNA Expression in Pigs Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology) Risk Factors for Microvascular Complications of Diabetes Among South Indian Subjects with Type 2 Diabetes?The Chennai Urban Rural Epidemiology Study (CURES) Eye Study-5 Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> UK watchdog calls for Glaxo's Avandia recall UK regulators call for the withdrawal across Europe of GlaxoSmith-Kline's diabetes drug Avandia (Source: FT.com - Drugs and Healthcare) Smoking and obesity critical to controlling diabetes levels Report shows improvement in diabetics? health with primary care, writes JOANNE HUNT (Source: The Irish Times - Health) Kardiomiopatia rozstrzeniowa i przerostowa u pÅ‚odu matki z cukrzyca ciezarnych - opis przypadku. We report a case of hypertrophic cardiomyopathy preceded with dilated cardiomyopathy in a fetus of a diabetic mother. The fetal echocardiography at the 23rd week of gestation revealed signs of dilated cardiomyopathy with signs of cardiac failure. Under the echocardiographic monitoring the successful treatment was performed. In spite of poor prognosis, the child was born at the 39th gestation week in a good condition. PMID: 20813091 [PubMed - as supplied by publisher] (Source: Pediatric Endocrinology, Diabetes, and Metabolism) [The importance of case reports in current pediatric endocrinology and metabolism literature - the analysis of publications indexed in Medline in the years 2004-2009.] Conclusion: Case reports remain an important contribution to the pediatric literature, mainly fulfilling an essential role in providing information about new medical problems. Medical literature published in Polish is relatively rich in clinical case reports. Publishing a case report in field of endocrinology and metabolism in Pubmed indexed journal is considered reasonable in situations where a new medical condition is being presented (most often a new mutation), a novel therapy has been discovered, the case is interesting or where the publishing of such reports fulfils didactic/educational needs. PMID: 20813090 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism) [Endocrine disorders in children after treatment for brain tumors.] Authors: Krawczuk-Rybak M Endocrine dysfunction is one of the most common late effect of anticancer treatment. The kind and degree of the disorder depend on tumor location, therapy, especially on the dose of radiotherapy, different sensitivity of the hypothalamo-pituitary axes to irradiation, as well as on the time of treatment. The growth hormone secretion axis is the most vulnerable part, and growth disorders occure most frequently (after a total dose of >30 Gy); then, after a total dose of 50-60 Gy: gonadotropin, ACTH deficiency, and, rarely, TSH deficiency. Spinal irradiation leads to the height loss and disproportionate growth as well as dysfunction of gonads and thyroid gland. Chemotherapy (alkylating agents) deteriorates gonadal function. The recognition, good and early diagn...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> [The role of FTO gene polymorphism in the pathogenesis of obesity.] Authors: Tercjak M, LuczyÅ„ski W, Wawrusiewicz-Kurylonek N, Bossowski A Both environmental and genetic factors play a role in the pathogenesis of obesity. At present, researchers are examining the genetic background of overweight. Over 100 genes are suspected to influence the obesity. One of those genes is FTO (fat mass and obesity-associated gene). In the manuscript, the relationship between FTO gene polymorphism (AA allele) and overweight, obesity and their consequences are discussed. It was proved, in studies on large number of people, that FTO gene polymorphism is related to higher body mass index, weight and abdominal circumference. Some authors showed that FTO gene polymorphism influences the food intake, energy expanditure and insulin resistance. The expression of FTO gene pro... [Evaluation of mental development of children with congenital hypothyroidism detected in screening test - personal observations.] Conclusions: 1. Mental development of the studied children with CH was within normal range. 2. Out of all measured parameters determining mental development, tasks in mathematics, analysis and synthesis, visual concentration and concentration on the hearing level had worst results. 3. The level of TSH in the screening test had no effect on the mental development of children with CH. 4. Out of all environmental factors, parental education influenced the mental development of the studied children. PMID: 20813087 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism) Budowa somatyczna oraz zdolnoÅ›Ä‡ zachowania rÃ³wnowagi dynamicznej dziewczat uprawiajacych gimnastyke artystyczna. Conclusion: Body constitution type in the qualified gymnasts is characterised by the prevalence of the ectomorphic component. The study results indicate that female gymnasts are generally slim and lean. It is necessary to monitor BMI in order to exclude weight-related disorders and to observe the changes with age. The poorest result was found when the gymnasts bent in the backward direction as this body position is most difficult to assume and to maintain body equilibrium as compared to all other directions. PMID: 20813086 [PubMed - as supplied by publisher] (Source: Pediatric Endocrinology, Diabetes, and Metabolism) [Agility in treatment of children with type 1 diabetes - pilot study.] This study showed that an interesting physical activity resulted in a more eager and systematic effort among examined diabetic children. Its proper organization in time may help in the metabolic control in children with type 1 diabetes. PMID: 20813085 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism) [Overweight, obesity and metabolic syndrome in children with type 1 diabetes melllitus.] Conclusions: The population of children with type 1 diabetes is characterized by high frequency of overweight/obesity, abdominal obesity, dyslipidemia and hypertension. The features of metabolic syndrome are less frequent. It is worthwhile to monitor the risk for development of cardiovascular diseases in this group of children. PMID: 20813084 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> L-karnityna obniza stres oksydacyjny indukowany eksperymentalnym niedotlenieniem hypobarycznym. Conclusion: This study suggests that the administration of L-carnitine can be beneficial in attenuating the oxidative stress associated with exposure to high altitude. PMID: 20813083 [PubMed - as supplied by publisher] (Source: Pediatric Endocrinology, Diabetes, and Metabolism) [Optimization of monogenic diabetes screening programme - initial report on recruitment efficacy of the TEAM project.] Conclusions: Periodic reevaluation of patients' data allows a significant increase in the number of candidates subjected to genetic screening and potentially achieving beneficial therapeutic effects by means of pharmacogenetics. PMID: 20813082 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism) [Evaluation of preserved insulin secretion in children and adolescents with type 1 diabetes.] Conclusion: Repeated measures of c-peptide can enable us to define two groups of patients with immune-mediated diabetes with different levels of disease and metabolic control. PMID: 20813081 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism) Engaging community pharmacists in the primary prevention of cardiovascular disease: protocol for the Pharmacist Assessment of Adherence, Risk and Treatment in Cardiovascular Disease (PAART CVD) pilot study This study will be a longitudinal pre- and post-test pilot study with a single cohort of up to 100 patients in ten pharmacies. Patients aged 50-74 years with no history of heart disease or diabetes, and taking antihypertensive or lipid-lowering medicines, will be approached for participation. Assessment of cardiovascular risk, medicines use and health behaviours will be undertaken by a research assistant at baseline and following the intervention (6 months). Validated interview scales will be used where available. Baseline data will be used by accredited medicines management pharmacists to generate a report for the treating community pharmacist. This report will highlight individual patients' overall CVD risk and individual risk factors, as well as identifying modifiable health behaviours ... Licensing process for top selling diabetes drug under fire Doctors should demand more rigorous proof of long term risks and benefits for diabetes drugsRelated items from OnMedicaAntihypertensive drugs vary in heart attack riskRisk/benefit balance of alteplase shifts quicklyCare homes drug error rate raises concernsFake medicine warning hits cinemasBenefits of statins 'still outweigh risks' (Source: OnMedica Latest News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Medical Journal Urges U.K. to Pull Avandia The British Medical Journal said diabetes drug Avandia should be withdrawn from sale. But GlaxoSmithKline said it has extensive documentation of the drug's benefits. (Source: WSJ.com: Health) U.K. Medical Journal Questions Avandia License The British Medical Journal said GlaxoSmithKline's diabetes drug should never have been licensed and should be withdrawn from sale, a claim the company rejected. (Source: WSJ.com: Health) British regulators want Avandia diabetes pill pulled British drug regulators say GlaxoSmithKline's controversial diabetes pill Avandia should be pulled from the U.K. market because of concerns that ... (Source: USATODAY.com Health) U.K. Medical Journal Says GSK's Avandia Should Be Pulled The British Medical Journal said GlaxoSmithKline's diabetes drug should never have been licensed and should be withdrawn from sale, a claim the company rejected. (Source: WSJ.com: Health) Concern About Rosiglitazone (Avandia) And How Drugs Are Regulated And Promoted, BMJ There is serious concern about top-selling diabetes drug rosiglitazone (Avandia), its safety, as well as the whole system by which medications are regulated, evaluated and promoted worldwide, according to a BMJ (British Medical Journal) investigation. Dr. Fiona Godlee, BMJ Editor-in-Chief, thinks Avandia should not have been licensed; she believes it should be withdrawn. There should be better access to raw data used to license drugs, as well as more robust regulatory processes, to allow examination by the scientific community, Godlee added... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> MHRA under pressure to withdraw rosiglitazone The UK drug regulator has come under fire for failing to act on an expert recommendation to withdraw the type 2 diabetes drug rosiglitazone. (Source: Pulse) Behavioral control is an important predictor of soy intake in adults in the USA concerned about diabetes. Authors: Li S, Camp S, Finck J, Winter M, Chapman-Novakofski K The primary objective of this study was to determine the variables associated with intention to consume soy products and identify key variables that could be used as targets in soy nutrition education and consumption promotion. A pre/post-test survey was used during a three session class focused on diabetes that discussed and introduced soy foods. The Theory of Planned Behavior framed the questions and variables examined. Subjective norms and behavioral control were most important in predicting intention to consume soy foods. Specifically, health experts and providers were important subjective norms; accessibility and ability to prepare were key behavioural control determinants. While most participants tried soy during the ... Commentary: What can we learn from the continuing regulatory focus on the thiazolidinediones? (Source: BMJ Online First) Rosiglitazone: what went wrong? (Source: BMJ Online First) Licensing drugs for diabetes (Source: BMJ Online First)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> International Study Led By VA-Harvard Physician Yields Insight On Risks From Fatty Arteries This study was an impressive international collaboration that may hold important clinical benefits for Veterans and others with cardiovascular disease," said VA Secretary Eric K. Shinseki... (Source: Health News from Medical News Today) Avandia Weighing up the benefits and risks of diabetes drug Avandia (Source: BHF National News) Heart news digest Diabetes drug, teeth brushing, Roman walk and a special 18th (Source: BHF National News) Now you can raise money for SfE! We’ve teamed up with the website JustGiving to enable you to donate and raise money for SfE online. JustGiving provides you with the tools to set up your own fundraising activities, including an easy to manage online sponsorship form, and it automatically reclaims GiftAid and sends the funds raised straight through to us. The funds raised will go towards the Society for Endocrinology’s activities in medical research, clinical practice and education. You can create a fundraising page for anything – drinking a gallon of milk for osteoporosis, eating a diabetic diet for a month, or reciting John F. Kennedy’s speeches for Addison’s disease - ask not what your hormones can do for you, but what you can do for your hormones! Go to www.justgiving.com/endocrinology... Diabetes drug still available despite suspension advice (BBC News Online, 6 September 2010) Despite concerns due to reportedly raised risks of heart attack and heart failure, the type 2 diabetes drug Avandia (generic name rosiglitazone) is still being widely prescribed in the UK. Full article (Source: Society for Endocrinology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Portal inflammation is associated with advanced histological changes in alcoholic and non-alcoholic fatty liver disease Conclusions Portal inflammation is a common component of histological spectrum of both AFLD and NAFLD. In both conditions portal inflammation is associated with clinical and histological features suggestive of advanced disease. (Source: Journal of Clinical Pathology) Uganda: Teso Diabetics Ask for Hospital Diabetes patients in Teso sub-region have asked the Government to construct a hospital which will treat and monitor the disease. (Source: AllAfrica News: Health and Medicine) Dangerous diabetes drug still prescribed despite warnings People with diabetes are still being prescribed a potentially dangerous drug two months after safety experts recommended it should be taken off the market. (Source: Nursing Times Breaking News) Uganda: Country Joins War Against Diabetes Uganda will be one of the first countries to benefit from a master plan to fight diabetes in Africa. (Source: AllAfrica News: Health and Medicine) Vended Foods And Beverages May Be Linked To Obesity, Diabetes And Coronary Artery Disease School children who consume foods purchased in vending machines are more likely to develop poor diet quality - and that may be associated with being overweight, obese or at risk for chronic health problems such as diabetes and coronary artery disease, according to research from the University of Michigan Medical School. The study also looked at foods sold in school stores, snack bars and other related sales that compete with USDA lunch program offerings and found that these pose the same health and diet risks in school-aged children... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Stem Cell Ruling Halts Sight-Saving Research The Association for Research in Vision and Ophthalmology (ARVO), a professional organization of member scientists, opposes the Federal District Court injunction that froze federal funding for human embryonic stem cell (hESC) research. ARVO is troubled by this barrier to research that has the potential to restore sight and mitigate eye damage. ARVO members investigate hESC therapies for treating diseases such as age-related macular degeneration (AMD), diabetic retinopathy, glaucoma and corneal disease, along with studies related to eye tissue transplantation, regeneration and engineering... (Source: Health News from Medical News Today) Diabetes drug Avandia still being prescribed despite heart risk fears A popular diabetes drug is still being prescribed two months after a safety body recommended its withdrawal amid concerns the drug can increase the risk of heart attacks. (Source: Telegraph Health) Heart attack risk of diabetes drug: Experts call for Avandia to be withdrawn A diabetes drug taken by up to 100,000 patients increases the risk of heart attacks and should be withdrawn on safety grounds, senior doctors say today. (Source: the Mail online \| Health) Most diabetics need better BP control to reach targets Belgian researchers report that only 16% of patients with Type 2 diabetes achieve the target blood pressure of 130/80 mmHg recommended by American and European regulatory bodies such as the European Society of Hypertension. (Source: MedWire News - Hypertension) Fish Oil?s Magic Revealed (Ivanhoe Newswire) ? Fish oil was deemed the ?miracle food of the 21st century? because of its anti-inflammatory and anti-diabetes benefits, among many others. (Source: Medical Headlines From Ivanhoe.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Saxagliptin: A dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes mellitus. Conclusion Saxagliptin, a DPP-4 inhibitor approved for the treatment of type 2 diabetes, demonstrated safety and efficacy in lowering HbA(1c), FPG, and PPG levels as both monotherapy and in combination with other oral antidiabetic medications. PMID: 20811029 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP) Use of concentrated insulin human regular (U-500) for patients with diabetes. Conclusion U-500 insulin is efficacious and safe for patients with type 2 diabetes who require a high dosage of insulin to control hyperglycemia. However, health care professionals should be well educated and vigilant about patient safety issues regarding the drug's prescription, dosing, and administration. PMID: 20811030 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP) GlaxoSmithKline responds to British Medical Journal article regarding Avandia® (rosiglitazone) GlaxoSmithKline (GSK) continues to work in the best interest of diabetes patients who face this chronic and serious disease. Patients taking Avandia should speak with their doctor about their treatment and any questions they may have regarding their medicine. (Source: GSK news) Doctors still prescribe diabetes drug despite heart attack warning A POPULAR diabetes drug is still being prescribed, two months after a safety body recommended its withdrawal amid concerns the drug can increase the risk of heart attacks. (Source: Scotsman.com News - Health) Children with Type 1 diabetes have early signs of atherosclerosis Study results show that children with Type 1 diabetes have significantly increased carotid intima media thickness, an early sign of atherosclerosis, compared with their nondiabetic peers. (Source: MedWire News - Diabetes)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Diabetes drug advice 'not heeded' A type two diabetes drug is still being prescribed in the UK two months after it is recommended for withdrawal, Panorama learns. (Source: BBC News \| Health \| UK Edition) UK wants GSK's Avandia pulled as EU reviews safety LONDON (Reuters) - GlaxoSmithKline's diabetes drug Avandia should be pulled from sale because of concerns about heart risks, British drug regulators said on Monday ahead of a special European meeting on the drug's safety. (Source: Reuters: Health) BBC Panorama report on rosiglitazone Source: BBC Health Area: News In a programme due to air tonight, BBC Panorama reports that rosiglitazone (Avandia®) is still being prescribed widely in the UK for type 2 diabetes, despite concerns over its cardiovascular safety.    The EMEA is currently undertaking a benefit-risk review of rosiglitazone-containing medicines - the CHMP is meeting this week (8th September) to discuss the ongoing review which is expected to be finalised at its next meeting (20-23rd September 2010).   According to a BBC Health report, an expert panel at the MHRA voted unanimously in July 2010 for the withdrawal of rosiglitazone from the UK; this recommendation was not however made public.  The Agency released a letter to healthcare professionals at this time outlining current pre... Increased expression and local accumulation of the prion protein, Alzheimer Abeta peptides, superoxide dismutase 1, and Nitric oxide synthases 1 & 2 in muscle in a rabbit model of diabetes Conclusions: The present study provides evidence that several classic amyloid and oxidative stress-related disease proteins coordinately increase in overall expression and form localized accumulations in diabetic muscle. The present study highlights the capacity of this wild-type animal model to produce an array of hallmark pathological features that have been also been described in other muscle diseases. (Source: BMC Physiology - Latest articles) Children Who Eat Vended Foods Face Health Problems, Poor Diet School children who consume foods purchased in vending machines are more likely to develop poor diet quality - and that may be associated with being overweight, obese or at risk for chronic health problems such as diabetes and coronary artery disease, according to research from the University of Michigan Medical School. The study also looked at foods sold in school stores, snack bars and other related sales that compete with USDA lunch program offerings and found that these pose the same health and diet risks in school-aged children... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Insulin pump therapy inequality There are major inequities in access to insulin pump therapy among patients with type 1 diabetes, according to a recent survey. (Source: Nursing Times Breaking News) Stem cell clinics: experts insist claims of cure-all are medically unproven Health tourists travel the world and spend thousands, but their hopes of being cured are likely to be dashedFor the past decade stem cells have sparked huge excitement among scientists, dramatic media coverage about breakthroughs that could mean a cure for some of the nastiest diseases, and hope ? sometimes desperate ? among patients that the reality will match the hype. That has fuelled a booming trade in stem cell tourism ? people heading to clinics abroad and forking out large sums for what are called stem cell treatments but which are unlikely to work and possibly do harm.It is, as some of the UK's leading stem cells experts warned last week, a world of unproven therapies, patient optimism and predatory clinicians. Despite the lack of reliable evidence underpinning the treatments... Justin Webb: 'I have to believe in miracles' The 'Today' presenter Justin Webb, whose son suffers from diabetes, explains how he was brought close to tears by an item on stem-cell treatment (Source: Telegraph Health) Why fish oils work swimmingly against inflammation and diabetes Researchers have identified the molecular mechanism that makes omega-3 fatty acids so effective in reducing chronic inflammation and insulin resistance. (Source: ScienceDaily Headlines) Forecasting: Patient Flow Modeling Comes Of Age - Pre-Summit Workshop October 5th Boston Judith Kulich, Associate Principal, and Emily Jin, Manager, at ZS Associates talk to eyeforpharma about how patient flow modeling can inform forecasting. Patient flow, or system dynamics forecasting is a common approach for modeling situations in which patient potential is affected by movement between disease states. The technique is used frequently in oncology, diabetes, RA, and other markets with lines of therapy dynamics... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Increased Risk of Death with Tygacil (Tigecycline) Compared to Other Antibiotics Used to Treat Similar Infections Source: Food and Drug Administration Related MedlinePlus Pages: Antibiotics, Diabetic Foot, Pneumonia (Source: MedlinePlus Health News) Key to fish oil "magic" found The mystery of how fish oil helps fight diabetes and heart disease may have been solved (Source: Nursing in Practice) Beta-1 adrenergic receptor polymorphism may increase LVH risk. The Arg389 polymorphism of the beta-1 adrenergic receptor is associated with a higher risk for left ventricular hypertrophy than is the Gly389 polymorphism in non-diabetic acute myocardial infarction survivors, researchers report. (Source: MedWire News - Diabetes) Treating Diabetes With Severe Personality-Disordered Individuals and Families Diabetes is an increasingly common chronic medical condition that affects not only patients but also their families. Ensuring adherence to a treatment regimen in diabetic patients is particularly challenging for physicians as well as counselors providing health-focused counseling. However, that challenge is exponentially increased when the patient and one or more family members manifest personality-disordered behavior that interferes with and complicates diabetic treatment. Diabetes as a chronic medical condition is described in the context of individual and family borderline dynamics. (Source: The Family Journal) Mouse Study May Help Explain Fish Oil?s Benefits Giving rodents omega-3 fatty acids helped counteract inflammation that can lead to diabetes (Source: The Doctors Lounge - Health News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Differential Diagnosis of Hereditary Nephrogenic Diabetes Insipidus with Desmopressin Infusion Test Conclusion  It is concluded that the desmopressin infusion test is a simple and reliable method for the diagnosis and differential diagnosis of HNDI in early childhood. Content Type Journal ArticleDOI 10.1007/s12098-010-0181-3Authors Zelal Bircan, Department of Pediatric Nephrology, Kocaeli University School of Medicine, Kocaeli, TurkeyHatice Mutlu, Department of Pediatrics, Kocaeli University School of Medicine, Kocaeli, TurkeyHae Il Cheong, Department of Pediatrics, Seoul National University Children?s Hospital and Kidney Research Institute, Seoul, Korea Journal Indian Journal of PediatricsOnline ISSN 0973-7693Print ISSN 0019-5456 (Source: Indian Journal of Pediatrics) Long Term Data Presented at ESC 2010 Further Support the Benefit of TheSirolimus Drug-Eluting Stent Compared to The ENDEAVOR(R) Zotarolimus-Eluting Stent in Important High-Risk Subgroups STOCKHOLM, September 2, 2010/PRNewswire/ --   - Additional Analysis of 18 Month Data of the SORT OUT III Trial Provides Detail on Safety and Efficacy Outcomes in Patients With Diabetes, Acute Coronary Syndrome, or Treatment of... (Source: Drugs.com - Clinical Trials) Protein test ups diabetes diagnoses in some races NEW YORK (Reuters Health) - Efforts to adopt a more accurate test for diagnosing diabetes may have hit a snag. Comparing the age-old oral glucose tolerance test to the newer hemoglobin A1c test confirms earlier evidence that race may influence test results, Danish researchers report. (Source: Reuters: Health) Enzymatic Function of Two Methylthiotransferase Families [Cell Biology] Bacterial and eukaryotic transfer RNAs have been shown to contain hypermodified adenosine, 2-methylthio-N6-threonylcarbamoyladenosine, at position 37 (A37) adjacent to the 3'-end of the anticodon, which is essential for efficient and highly accurate protein translation by the ribosome. Using a combination of bioinformatic sequence analysis and in vivo assay coupled to HPLC/MS technique, we have identified, from distinct sequence signatures, two methylthiotransferase (MTTase) subfamilies, designated as MtaB in bacterial cells and e-MtaB in eukaryotic and archaeal cells. Both subfamilies are responsible for the transformation of N6-threonylcarbamoyladenosine into 2-methylthio-N6-threonylcarbamoyladenosine. Recently, a variant within the human CDKAL1 gene belonging to the e-MtaB subfamily was... Metformin Might Prevent Colorectal, Lung Cancers The old, cheap diabetes drug metformin is attracting notice as a chemoprevention agent. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> NIHR Clinical Lecturer in Endocrinology and Diabetes (NTN(A) attached) - University of Sheffield Up to two National Institute for Health Research Clinical Lectureship posts are available at the University of Sheffield offering a programme of integrated training in clinical academic medicine. The posts are open to a number of specialties, endocrinology and diabetes being one, and are available for four years or until the post holder obtains their CCT. They must also have successfully completed a PhD or MD and must be eligible for or in posession of a National Training Number (NTN). The deadline for applications is 5 October 2010. For more information please follow the link below. Further details (Source: Society for Endocrinology) Differential Contribution of Diabetes and the Ren2 Gene to Glomerular Pathology in Diabetic (mREN-2)27 Rats Narrowing the scope of utility for (mREN-2)27 rats may help to create better methods for researching diabetic nephropathy. Laboratory Investigation (Source: Medscape Today Headlines) Fatty acids 'may prevent diabetes' The secret of how fish oil helps prevent heart disease and diabetes is believed to have been unlocked by scientists who now hope to develop new dietary remedies and drugs to reduce conditions such as type-2 diabetes, heart disease and arthritis. (Source: Nursing Times Breaking News) Longitudinal examination of cervical volume and vascularization changes during the antepartum and postpartum period using three-dimensional and power Doppler ultrasound Journal of Perinatal Medicine 38 (5): 461-465 Abstract Objective: To assess longitudinally the changes in cervical volume and vascularization during the peripartum period using three-dimensional ultrasound (3D US) and power Doppler and to determine whether these measures change with gestational complications. Methods: Longitudinal measurements of cervical dimensions by transvaginal 3D US and power Doppler using the virtual organ computer-aided analysis program were performed at 11?14, 22?24, 32?34 weeks' gestation, and at 6 weeks' postpartum in 111 pregnant women. Comparisons were made between women who delivered at term (vs. preterm), nulliparous (vs. parous), with (vs. without) pre-eclampsia and those with (vs. without) gestational diabetes. Results: After establishing reference ... Pcif1 modulates Pdx1 protein stability and pancreatic {beta} cell function and survival in mice The homeodomain transcription factor pancreatic duodenal homeobox 1 (Pdx1) is a major mediator of insulin transcription and a key regulator of the β cell phenotype. Heterozygous mutations in PDX1 are associated with the development of diabetes in humans. Understanding how Pdx1 expression levels are controlled is therefore of intense interest in the study and treatment of diabetes. Pdx1 C terminus–interacting factor-1 (Pcif1, also known as SPOP) is a nuclear protein that inhibits Pdx1 transactivation. Here, we show that Pcif1 targets Pdx1 for ubiquitination and proteasomal degradation. Silencing of Pcif1 increased Pdx1 protein levels in cultured mouse β cells, and Pcif1 heterozygosity normalized Pdx1 protein levels in Pdx1+/– mouse islets, thereby increasing ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> How do organisms make dietary choices? When given a choice, organisms will choose a diet that maintains a nutritional balance in tune with their needs. That choice, studied in fruit flies for the first time, is regulated by activity in a molecular pathway involved in aging, cancer and diabetes. Humans share the same molecular pathway. The study, the first to be done in a genetically tractable lab animal, could lead to treatments that would "reboot" metabolic pathways in individuals who are obese or suffer from diabetes. (Source: ScienceDaily Headlines) Children who eat vended snack foods face chronic health problems, poor diet, study finds School children who consume foods purchased in vending machines are more likely to develop poor diet quality -- and that may be associated with being overweight, obese or at risk for chronic health problems such as diabetes and coronary artery disease, according to new research. (Source: ScienceDaily Headlines) An Economic Evaluation of Colesevelam when Added to Metformin-, Insulin- or Sulfonylurea-Based Therapies in Patients with Uncontrolled Type 2 Diabetes Mellitus (Source: PharmacoEconomics) Factor Structure and Measurement Invariance of a 10-Item Decisional Balance Scale: Longitudinal and Subgroup Examination Within an Adult Diabetic Sample (Source: Measurement in Physical Education and Exercise Science) Frequent Reoccurrence of Hypoglycemia in a Type 2 Diabetic Patient with Insulin Antibodies (Source: Molecular Diagnosis)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Dr Oz colon polyps raises question of "spontaneous disease" without cause (NaturalNews) Dr Oz was recently found to have a precancerous colon polyp which was surgically removed. Following this experience, he appears to be surprised and confused about the origin of the condition, and he credits colonoscopy screening with saving his life.Dr Oz even seems to think he has a perfect health record, saying, "I have done everything right. I don't have any family history, and yet I'm high risk now." His personal physician, meanwhile, is implying that even though Dr Oz's "healthy" diet was perfect, it wasn't enough to prevent colon polyps, and therefore you might get them too. (And therefore everybody should get screened...)Dr Jonathan Lapook, went on to say "...no matter what you do, you can't totally eliminate your risk of developing this disease, which is expected to s... Americans Blind to the Obesity Epidemic Title: Americans Blind to the Obesity EpidemicCategory: Health NewsCreated: 9/2/2010 10:10:00 AMLast Editorial Review: 9/3/2010 (Source: MedicineNet Diabetes General) Vets With Stress Disorder More Likely to Develop Dementia Title: Vets With Stress Disorder More Likely to Develop DementiaCategory: Health NewsCreated: 9/2/2010 10:10:00 AMLast Editorial Review: 9/3/2010 (Source: MedicineNet Diabetes General) Association of doctor specialty with diabetic patient risk of hospitalization due to diabetic ketoacidosis: a national population?based study in Taiwan (Source: Journal of Evaluation in Clinical Practice) Mild BNP may indicate LV dysfunction in diabetics Dutch researchers report that slightly elevated B-type natriuretic peptide levels are associated with increased left ventricular mass and diastolic dysfunction in patients with Type 2 diabetes. (Source: MedWire News - Diabetes)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Celebrating World Diabetes Day and preparing for the battles ahead (Source: Diabetes Research and Clinical Practice) Influence of Left Ventricular Dysfunction (Diastolic Versus Systolic) on Long-Term Prognosis in Patients With Versus Without Diabetes Mellitus Having Elective Peripheral Arterial Surgery In conclusion, diabetic patients with PAD have an increased prevalence of isolated systolic and combined LVD. In patients with PAD the presence of isolated diastolic, systolic, or combined LVD was independently and equally associated with increased cardiovascular mortality, irrespective of the concomitant presence of DM. (Source: The American Journal of Cardiology) If you have prediabetes, do something about it now Prevent or delay diabetes by changing your lifestyle. (Source: MayoClinic.com Full Feed) Children And Vending Machines Don?t Mix Well (Ivanhoe Newswire) - School children who consume foods purchased in vending machines are more likely to develop poor diet quality ? and that may be associated with being overweight, obese or at risk for chronic health problems such as diabetes and coronary artery disease, according to research from the University of Michigan Medical School. (Source: Medical Headlines From Ivanhoe.com) NPRI partners launch £10m funding call to tackle major health threats A £10 million fund has been committed by The National Prevention Research Initiative (NPRI), managed by the MRC, in its drive to prevent some of the UK’s most prominent diseases and conditions, such as cancer, diabetes, obesity, stroke and dementia. (Source: Medical Research Council Funding News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Elevated blood glucose disrupts normal immune responses in diabetics UK researchers suggest that elevated blood glucose levels in patients with diabetes can cause competitive inhibition of immune receptors and hinder the body?s ability to fight infection. (Source: MedWire News - Diabetes) Involvement of the Basilar Artery in Diabetes Mellitus: An MRI Study of Brainstem Infarctions Eur Neurol 2010;64:230â€“235 (DOI:10.1159/000319924) (Source: Karger Publishers) Peroxisome Proliferator-Activated Receptor-Î³ Agonist Rosiglitazone Prevents Albuminuria but Not Glomerulosclerosis in Experimental Diabetes Am J Nephrol 2010;32:393â€“402 (DOI:10.1159/000320129) (Source: Karger Publishers) Diabetes Drug Metformin Linked to Lower Lung Cancer Rate in Mice Findings reflect those of population studies in humans, researchers say (Source: Pharmacy News - Doctors Lounge) Bariatric Surgery Cost-Effective in Very Obese With Diabetes Both gastric bypass and gastric banding are cost-effective ways to reduce diabetes-associated complications and mortality among severely obese individuals with diabetes, according to research published in the September issue of Diabetes Care. (Source: Modern Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic ?-cells: protective role of p62-positive cytoplasmic inclusions Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions Cell Death and Differentiation advance online publication, September 3, 2010. doi:10.1038/cdd.2010.111 Authors: J F Rivera, T Gurlo, M Daval, C J Huang, A V Matveyenko, P C Butler & S Costes (Source: Cell Death and Differentiation) Lead Exposure May Delay Puberty in Girls Occurred even at blood levels below those recommended for treatment, NIH found (Source: The Doctors Lounge - Endocrinology and Diabetes) 14th Annual Meeting of the Neuroendocrinology Section of the German Society of Endocrinology (DGE) and 20th Anniversary of an Argentine-German Collaboration Experimental and Clinical Endocrinology & Diabetes 2010; 08Article in Thieme eJournal:Table of contents \| Congress (Source: Experimental and Clinical Endocrinology and Diabetes) Plasma bile acids are not associated with energy metabolism in humans Bile acids (BA) have recently been shown to increase energy expenditure in mice, but this concept has not been tested in humans. Therefore, we investigated the relationship between plasma BA levels and energy expenditure in humans. Type 2 diabetic (T2DM) patients (n=12) and gender, age and BMI-matched healthy controls (n=12) were studied before and after 8 weeks of treatment with a BA sequestrant. In addition, patients with liver cirrhosis (n=46) were investigated, since these display elevated plasma BA together with increased energy expenditure. This group was compared to gender-, age- and BMI-matched healthy controls (n=20).Fasting plasma levels of total BA and individual BA species as well as resting energy expenditure were determined. In response to treatment with the BA sequestrant, p... A1C Usefulness in Detecting New Diabetes Limited Testing serum A1C levels is less sensitive for detecting individuals at risk for diabetes than other tests, but can be used for ongoing screening and diagnosis in those whose baseline A1C is already elevated, according to research published in the September issue of Diabetes Care. (Source: Modern Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Ezetimibe/Simvastatin Combo Lowers LDL in Type 2 Diabetes For patients with type 2 diabetes who are not meeting recommended low-density lipoprotein cholesterol goals, adding ezetimibe to simvastatin treatment significantly increases the likelihood of reaching a low-density lipoprotein cholesterol level below 70 mg/dL, according to a study published in the September issue of Diabetes Care. (Source: Modern Medicine) Physician's Focus: Options for Erectile Dysfunction The National Institute of Diabetes and Digestive and Kidney Diseases states that between 15 and 30 million men in the United States are affected by erectile dysfunction (ED). Regardless of the root cause, your patients will be reassured to know that want to know that ED can be treated. ModernMedicine has the resources you need to inform them of the options. (Source: Modern Medicine) Low Vitamin D Level May Raise Risk of Type 2 Diabetes Having a higher plasma 25-hydroxyvitamin D concentration appears to decrease the risk of type 2 diabetes in women, independent of other risk factors, according to a study published in the September issue of Diabetes Care. (Source: Modern Medicine) Early Severe Hypoglycemia Tied to Poorer Cognition Exposure to severe hypoglycemia at an early age may negatively impact long-term cognitive function in individuals with type 1 diabetes, according to a study published in the September issue of Diabetes Care. (Source: Modern Medicine) FVB mouse genotype confers susceptibility to OVE26 diabetic albuminuria OVE26 (OVE) diabetic mice on the inbred strain FVB are a valuable model of diabetic nephropathy that excretes the highest amount of urine albumin of all diabetic mouse models. Crossing of OVE mice to C57BL6 or DBA2 mice reduced albuminuria 17-fold in F1 diabetic offspring without reducing diabetes. When comparing renal histology of OVE mice on the FVB background to F1 C57BL6 crosses, we found that the F1 kidneys had significantly smaller glomeruli, much less albumin accumulation in tubules, reduced mesangial matrix expansion, and less interstitial fibrosis. A genome scan of 108 OVE-positive N2 offspring for albuminuria revealed one significant peak on chromosome 11 and nearly significant peaks on chromosomes 9, 13, and 19. Homozygosity for the FVB genotype for peaks on chromosomes 11, 13, ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> The pleiotropic actions of rosuvastatin confer renal benefits in the diabetic Apo-E knockout mouse In conclusion, in the diabetic Apo-E–/– mouse, rosuvastatin confers renal benefits that are independent of lipid lowering and equivalent or greater to those observed with candesartan. The combination treatment is not superior to monotherapies. (Source: AJP: Renal Physiology) Expression patterns of connective tissue growth factor and of TGF-{beta} isoforms during glomerular injury recapitulate glomerulogenesis Transforming growth factor (TGF)-β1, -β2, and -β3 are involved in control of wound repair and development of fibrosis. Connective tissue growth factor (CTGF) expression is stimulated by all TGF-β isoforms and is abundant in glomerulosclerosis and other fibrotic disorders. CTGF is hypothesized to mediate profibrotic effects of TGF-β1 or to facilitate interaction of TGF-β1 with its receptor, but its interactions with TGF-β isoforms in nonpathological conditions are unexplored so far. Tissue repair and remodeling may recapitulate gene transcription at play in organogenesis. To further delineate the relationship between CTGF and TGF-β, we compared expression patterns of CTGF and TGF-β isoforms in rat and human glomerulogenesis and in various human g... School Children Who Eat Vending Machine Foods Face Increased Risks for Chronic Health Problems, Poor Diet September 2, 2010 (U-M) - School children who consume foods purchased in vending machines are more likely to develop poor diet quality ? and that may be associated with being overweight, obese or at risk for chronic health problems such as diabetes and coronary artery disease, according to research from the University of Michigan Medical School. The study also looked at foods sold in school stores, snack bars and other related sales that compete with USDA lunch program offerings and found that these pose the same health and diet risks in school-aged children. read more (Source: Diabetes News from dLife.com) Acasti Pharma Inc. Reports Positive Impacts on Cardiometabolic Associated Disorders LAVAL, Quebec, Sept. 2, 2010 (GLOBE NEWSWIRE) -- This release replaces and supersedes the press release sent earlier today. Acasti Pharma Inc., a subsidiary of Neptune Technologies & Bioressources Inc. ("Neptune") (Nasdaq:NEPT) (TSX-V:NTB) reports significant results on the effects of its anti-dyslipidemic investigational drug candidate CaPre(tm) on C-reactive protein (CRP) levels, a biomarker of CardioVascular Disease risk (CVD) and associated with diabetes and obesity. (Source: Medical News (via PRIMEZONE)) Sugar not a painkiller for babies Conclusion This study has used objective measures of pain in a small sample of infants and used careful blinding and randomisation to reduce bias. There are a few limitations due to the study size, but the conclusions are likely to challenge the currently held belief that sugar is an effective treatment for the pain of minor procedures in infants. The limitations mentioned by the researchers were: The small sample size of 44 infants analysed, which could mean that this study was not powered to observe subtle effects that sucrose might have on the brain processes used for pain. A measure of pain in infants is necessarily indirect (because they cannot describe the sensation), and so even though the electrophysiological measures reported in this study are more objective it is not clear ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> How Fish Oil Fights Inflammation Omega-3 fatty acids work via a specific receptor and may combat diabetes as well (Source: ScienceNOW) Moving Diabetes Genetics Beyond Genome-Wide Association Studies Dr. Ali Torkamani summarizes key sessions from the American Diabetes Association's 70th Scientific Sessions and discusses how genetic investigations can assist in our understanding of type 1 and type 2 diabetes. Medscape Genomic Medicine (Source: Medscape Pathology Headlines) Lower Blood Pressure Goal Benefits African-Americans with Chronic Kidney Disease, Protein in the Urine Source: National Institute of Diabetes and Digestive and Kidney Diseases - Related MedlinePlus Pages: African-American Health, Kidney Diseases (Source: MedlinePlus Health News) Long Term Data Presented at ESC 2010 Further Support the Benefit of The CYPHER(R) Sirolimus Drug-Eluting Stent Compared to The ENDEAVOR(R) Zotarolimus-Eluting Stent in Important High-Risk Subgroups Additional Analysis of 18 Month Data of the SORT OUT III Trial Provides Detail on Safety and Efficacy Outcomes in Patients With Diabetes, Acute Coronary Syndrome, or Treatment of Multiple Lesions STOCKHOLM, September 2, 2010 (HSMN NewsFeed) --Three ne... Devices, Interventional CardiologyCordis, CYPHER, Sirolimus, Drug Eluting Stent, Zotarolimus, Medtronic (Source: HSMN NewsFeed) High-Risk Pools for the Sick and Uninsured Under Health Reform: Too Little and Thus Too Late ABSTRACT  Democrats and Republicans have turned to the concept of ?high-risk pools? to provide health care for those Americans who face the dual challenge of uninsurance and serious health difficulties. Under the Patient Protection and Affordable Care Act (PPACA), these ?high-risk? individuals will receive extensive help and regulatory protections, in concert with a new system of health insurance exchanges. However, these federal provisions do not become operational until 2014. As an interim measure, PPACA provides $5 billion for temporary, federally funded high-risk pools, now known as the Pre-Existing Condition Insurance Plan (PCIP). This analysis explores the adequacy of such funding. Using 2005/06 data from the National Health and Nutrition Examination Survey (N...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Plasma osteoprotegerin, arterial stiffness, and mortality in normoalbuminemic Japanese hemodialysis patients Conclusions  In long-term normoalbuminemic Japanese hemodialysis patients, with low prevalence of inflammation, OPG levels were strongly linked with both arterial stiffness and worse outcome. Content Type Journal ArticleDOI 10.1007/s00198-010-1377-0Authors A. Nakashima, Department of Advanced Nephrology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi Minami-Ku, Hiroshima, 734-8551 JapanJ. J. Carrero, Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, SwedenA. R. Qureshi, Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, SwedenT. Hirai, Department of Internal Medi... Better collaboration between primary and secondary doctors is key to integrated care (Source: BMJ Online First) Better collaboration between primary and secondary doctors is key to integrated care (Source: BMJ Online First) EMAS Publishes Position Statements About the Post-Reproductive Health of Women September 2, 2010 (EurekAlert) - Elsevier announced today the publication of four important position statements from the European Menopause and Andropause Society (EMAS) in the journal Maturitas on common management problems in the post-reproductive health of women. The statements cover the management of the menopause in the context of obesity, epilepsy, endometriosis and premature ovarian failure. Each statement has summary recommendations as a quick aid for the busy clinician. read more (Source: Diabetes News from dLife.com) Americans Blind to the Obesity Epidemic Harris Interactive/HealthDay poll finds 30 percent of those overweight think they're normal size (Source: The Doctors Lounge - Cardiology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Diabetes 2 Drug Metformin May Protect Against Lung Cancer In Smokers Two studies reveal that smokers may have a significantly lower risk of developing lung cancer and colorectal cancer with the drug metformin, which is commonly prescribed for diabetes type 2 treatment, the medical journal Cancer Prevention Research informs. Metformin, originally sold as Glucophage, is the first-line drug of choice for diabetes type 2 patients, especially those who are obese or overweight, as well as diabetes patients with normal kidney function. Metformin may have the following brand names: Fortamet, Glucophage, Glucophage XR, Glumetza, or Riomet... (Source: Health News from Medical News Today) Halozyme Begins Phase 2 Clinical Trials With Insulin Analogs Lispro and Aspart With rHuPH20 In Type 1 And Type 2 Diabetes Halozyme Therapeutics, Inc. (Nasdaq: HALO) today announced the initiation of two Phase 2 Ultrafast Insulin treatment studies that utilize its rHuPH20 hyaluronidase enzyme (PH20) in combination with the two leading commercially available mealtime analogs: insulin aspart, the active ingredient in NovoLog®, and insulin lispro, the active ingredient in Humalog®. (Source: Pharmaceutical Online News) Obesity runs Cali a $21B tab, and $24B for diabetes Rates of obesity and diabetes in California are well above the national targets and goals. In the state, costs related to obesity are reported to be $21 billion, and as the rate of diabetes jumped 26 percent from 2001 to 2007, direct costs related to the comorbidity have been reported to soak up $24 billion, according to the results of the most recent California Health Interview Survey. (Source: Cardiovascular Business News) Acasti Pharma Inc. Reports Positive Impacts on Obesity and Cardiometabolic Associated Disorders LAVAL, Quebec, Sept. 2, 2010 (GLOBE NEWSWIRE) -- Acasti Pharma Inc., a subsidiary of Neptune Technologies & Bioressources Inc. ("Neptune") (Nasdaq:NEPT) (TSX-V:NTB) reports significant results on the effects of its anti-dyslipidemic investigational drug candidate CaPre(tm) on C-reactive protein (CRP) levels, a biomarker of CardioVascular Disease risk (CVD) and associated with diabetes and obesity. (Source: Medical News (via PRIMEZONE)) Correlation between fluorescein angiography and spectral-domain optical coherence tomography in the diagnosis of cystoid macular edema Conclusions SD-OCT demonstrated greater sensitivity than FA in detecting CME, particularly those associated with RVO, DR and age-related macular degeneration. SD-OCT was also more sensitive than FA for detecting subretinal fluid and late complications of long-standing CME. (Source: British Journal of Ophthalmology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Central retinal thickness measured with HD-OCT shows a weak correlation with visual acuity in eyes with CSME Conclusion Correlations between RT and BCVA in CSME are only present when the central 500-µm-diameter circle is involved. However, even in this circumstance, a correlation was found in only 48.8% of the cases. RT cannot, therefore, be used as a surrogate outcome for visual acuity changes. (Source: British Journal of Ophthalmology) Plasma levels of vascular endothelial growth factor and pigment epithelium-derived factor before and after intravitreal injection of bevacizumab Conclusions The decreased levels of blood VEGF after an intravitreal injection of bevacizumab indicate that bevacizumab enters the general circulation and may also affect the PEDF levels. Thus, we should carefully examine patients for systemic changes and the fellow eye after an intravitreal injection of bevacizumab. (Source: British Journal of Ophthalmology) Entry site treatment to prevent late recurrent postoperative vitreous cavity haemorrhage after vitrectomy for proliferative diabetic retinopathy Conclusion This study suggests that inner sclerostomy site treatment is effective in reducing the occurrence of recurrent late POVCH in patients undergoing vitrectomy for PDR. A randomised controlled study is needed to clarify this. (Source: British Journal of Ophthalmology) Insulin resistance and diabetic macular oedema in type 2 diabetes mellitus Conclusions The findings of this study indicate a relationship between insulin resistance and cystoid macular oedema that unrelated to the use of insulin. Insulin treatment was associated with diffuse macular oedema. (Source: British Journal of Ophthalmology) Is age a risk factor for diabetic retinopathy? (Source: British Journal of Ophthalmology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> The prevalence and causes of visual impairment in indigenous Australians within central Australia: the Central Australian Ocular Health Study Conclusion This study indicates that bilateral visual impairment and blindness are, respectively, 25.1% and 3.6% among indigenous Australians, four to seven times higher than among the non-indigenous Australian population. Trachoma is the leading cause of bilateral blindness after refractive error and cataract. (Source: British Journal of Ophthalmology) Agent Orange Cases Expanded; Added Costs Raise Fiscal Concerns The Associated Press/Washington Post: Hundreds of thousands of Vietnam War veterans are receiving disability compensation for diseases normally associated with aging - not combat - because of the possibility of a link Agent Orange exposure. The diseases in question range from diabetes, for which 270,000 veterans receive Agent Orange-related checks, to erectile dysfunction. "And taxpayers may soon be responsible for even more: VA said Monday that it will add heart disease, Parkinson's disease and certain types of leukemia to the list of conditions that might be connected to Agent Orange... (Source: Health News from Medical News Today) Familial prevalence of autoimmune disorders in multiple sclerosis in Northern Greece Conclusions: There is a longitudinally increased frequency of additional autoimmune disorders among multiple sclerosis family members, probably related to immunomodulatory therapy. (Source: Multiple Sclerosis) Coronary revascularisation in the patient with diabetes: balancing risk and benefit (Source: Heart) Association between admission hypoglycaemia and in-hospital and 3-year mortality in older patients with acute myocardial infarction Conclusions In older patients with AMI, increased as well as decreased admission FPG levels could predict higher in-hospital and 3-year mortality. There was a striking U-shaped relationship between admission FPG levels and short- and long-term mortality. An initial admission FPG level ≥ 5.1 to≤7.0 mmol/l may be desirable because it was associated with better clinical outcomes. (Source: Heart)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Unilife Corporation Secures FDA 510k Clearance For The Unitract? 1mL Tuberculin Syringe Unilife Corporation ("Unilife" or "Company") (Nasdaq: UNIS, ASX: UNS), announced that its Unitract? Tuberculin (TB) Syringe has received 510(k) market clearance from the U.S. Food and Drug Administration (FDA). The Unitract? TB syringe is a variant of the Unitract? 1mL Insulin Syringe for which Unilife secured FDA clearance earlier this year. Unlike insulin syringes which are primarily used by people with diabetes, TB syringes are used for the administration of a range of therapeutic drugs and vaccines within acute-care hospitals and other healthcare facilities... (Source: Health News from Medical News Today) Azathioprine as an alternative treatment in primary hypophysitis Abstract  Primary hypophysitis (PH) is an unusual disorder characterized by inflammatory infiltration of the pituitary gland with various degree of pituitary dysfunction. Glucocorticoids are the treatment of choice in the majority of patients. Still, in patients with poor response in glucocorticoids or when their administration is accompanied with serious side effects, the use of alternative agents should be considered; up to now, data on other therapeutic approaches remains scant mainly due to the rarity of the disease. Among them, the immunosuppressant azathioprine could represent an effective and safe alternative. In this article, we present our clinical experience of two cases with PH successfully treated with azathioprine following serious side effects after initial tr... Telemedicine Helps Native Americans Source: Carolyn Bloch, Federal Telemedicine News Content: “The University of California, Davis School of Medicine is using grant funding to train Native American communities in the state. The training sites include the Round Valley Indian Tribes of Covelo, Mendocino County, and communities served by Northern Valley Indian Health Inc. that includes Glenn County and portions [...] (Source: ICMCC: The International Council on Medical and Care Compunetics) Bone Loss in Diabetes: Use of Antidiabetic Thiazolidinediones and Secondary Osteoporosis Abstract  Clinical evidence indicates that bone status is affected in patients with type 2 diabetes mellitus (T2DM). Regardless of normal or even high bone mineral density, T2DM patients have increased risk of fractures. One class of antidiabetic drugs, thiazolidinediones (TZDs), causes bone loss and further increases facture risk, placing TZDs in the category of drugs causing secondary osteoporosis. Risk factors for development of TZD-induced secondary osteoporosis are gender (women), age (elderly), and duration of treatment. TZDs exert their antidiabetic effects by activating peroxisome proliferator-activated receptor-? (PPAR-?) nuclear receptor, which controls glucose and fatty acid metabolism. In bone, PPAR-? controls differentiation of cells of mesenchymal and hemato... The Role of Renin-Angiotensin Agents in Altering the Natural History of Type 2 Diabetes Mellitus Abstract  Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease (CVD) morbidity and mortality worldwide. Renin-angiotensin system (RAS) blockers have been indispensable in diminishing the macrovascular and microvascular complications of diabetes. In addition, cumulative evidence from retrospective studies pointed toward a beneficial effect of RAS agents in preventing the development and progression of T2DM. This disease-modifying potential of RAS blockers has been substantiated by recent prospective trials. Contemporary concepts regarding the natural history of T2DM and the pathophysiologic processes involved have increased our understanding of the mechanisms underlying the therapeutic potential of these agents in diabetes management. In addition...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div> Original Article: Potential CYP2C9?mediated drug?drug interactions in hospitalized type 2 diabetes mellitus patients treated with the sulphonylureas glibenclamide, glimepiride or glipizide Abstract.? (Source: Journal of Internal Medicine) pSivida Announces Iluvien(R) Receives FDA Priority Review For Treatment Of Diabetic Macular Edema pSivida Corp. (NASDAQ:PSDV) (ASX:PVA), a leader in the development of sustained release back of the eye drug delivery systems for difficult-to-treat conditions, announced that its licensee, Alimera Sciences (NASDAQ:ALIM) has been notified that the U.S. Food and Drug Administration (FDA) has granted Priority Review status for the New Drug Application (NDA) filed for Iluvien for the treatment diabetic macular edema (DME). FDA Priority Review status is given to therapies that offer major advances in treatment, or provide a treatment where no adequate therapy exists... (Source: Health News from Medical News Today) New Study Singles Out Factors Linked To Cognitive Deficits In Type 2 Diabetes Older adults with diabetes who have high blood pressure, walk slowly or lose their balance, or believe they're in bad health, are significantly more likely to have weaker memory and slower, more rigid cognitive processing than those without these problems, according to a new study published by the American Psychological Association. These three health factors stood out from more than a dozen suspected to shape how Type 2 diabetes is frequently shadowed by cognitive impairment, including dementia... (Source: Health News from Medical News Today) Growing Obesity, Diabetes Epidemics In California A majority of adults in California are obese or overweight, and more than 2 million have been diagnosed with diabetes, according to a new study from the UCLA Center for Health Policy Research. Both conditions - which are related to each other as well as to heart disease - increased significantly in just six years, with the prevalence of diabetes alone jumping nearly 26 percent between 2001 and 2007. The "epidemic" of obesity and diabetes leaves no racial, ethnic, economic or geographic segment of the state unscathed, according to the researchers... (Source: Health News from Medical News Today)

types of diabetes guide

Diabetes: Breast-feeding May Help Babies And Women Against Diabetes
By Hector Milla
Babies and women may be protected against developing disease through breast feeding, according to new research. This current study states that the longer women nursed, the lower their risks of developing diabetes.

Diabetes as a medical disorder characterized by varying or persistent elevated blood sugar levels, especially due to eating, is a serious disease which symptoms are very similar for all types of diabetes.
Breast feeding is when a woman feeds a baby or a young child with milk produced from her breasts. The best thing for feeding a baby is breast milk, as experts say, if the mother does not have transmissible infections.
Although study findings are not conclusive, researchers explain that breast-feeding may change metabolism of mothers which may help keep blood sugar levels stable and make the body more sensitive to the blood sugar-regulating hormone insulin.

This theory is based on some evidence that show that in rats and humans that are breast-feeding, mothers have lower blood-sugar levels than those who did not breast-feed.

According to the study published in the Journal of the American Medical Association, women who breast-fed for at least one year were about 15 per cent less likely to develop type 2 than those who never breast-fed. For each additional year of breast-feeding, there was an additional 15 per cent decreased risk.

A total of 157,000 nurses participated in the new study. They answered periodic health questionnaires and were followed for at least 12 years. During the study, 6,277 participants developed type 2 diabetes.

Article written by Hector Milla editor of http://www.mydiabetessupply.com, a website about testing supply, or you may read their last article :: Diabetes:

High Blood Sugar Symptoms :: at http://www.mydiabetessupply.com/1/diabetes-high-blood-sugar-symptoms.html. Thanks for using this article in your website or ezine keeping a live link

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Article written by Hector Milla editor of www.mydiabetessupply.com, a website about diabetes testing supply, or you may read their last article :: Information on High Blood Sugar Symptoms :: at www.mydiabetessupply.com/1/diabetes-high-blood-sugar-symptoms.html. Thanks for using this article in your website or ezine keeping a live link.